Sucking genes into pores: Insight into driven translocation

被引:110
作者
Sakaue, Takahiro [1 ,2 ]
机构
[1] Kyushu Univ 33, Dept Phys, Fukuoka 8128581, Japan
[2] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan
来源
PHYSICAL REVIEW E | 2010年 / 81卷 / 04期
关键词
POLYMER TRANSLOCATION; DNA; NANOPORES;
D O I
10.1103/PhysRevE.81.041808
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
Flexible polymers such as long DNA, RNA molecules, and proteins, can pass through a narrow pore whose size is comparable to their molecular thickness. We highlight the richness and complexity involved in the dynamics of this unique mode of molecular transport, called translocation, actively driven by external forces. In particular, the process takes place in the condition far from equilibrium accompanying of large conformational distortion in line with the propagation of the tensile force along the chain backbone. A general framework is proposed, which captures such essential features, whereby can account for reported various experimental data from a unified viewpoint.
引用
收藏
页数:6
相关论文
共 34 条
  • [21] Driven polymer translocation through nanopores: Slow-vs.-fast dynamics
    Luo, K.
    Ala-Nissila, T.
    Ying, S. -C.
    Metzler, R.
    [J]. EPL, 2009, 88 (06)
  • [22] Dynamical scaling exponents for polymer translocation through a nanopore
    Luo, Kaifu
    Ollila, Santtu T. T.
    Huopaniemi, Ilkka
    Ala-Nissila, Tapio
    Pomorski, Pawel
    Karttunen, Mikko
    Ying, See-Chen
    Bhattacharya, Aniket
    [J]. PHYSICAL REVIEW E, 2008, 78 (05):
  • [23] Polymer translocation through a nanopore under an applied external field
    Luo, KF
    Huopaniemi, I
    Ala-Nissila, T
    Ying, SC
    [J]. JOURNAL OF CHEMICAL PHYSICS, 2006, 124 (11)
  • [24] Polymer translocation through a hole
    Muthukumar, M
    [J]. JOURNAL OF CHEMICAL PHYSICS, 1999, 111 (22) : 10371 - 10374
  • [25] EXCLUDED VOLUME EFFECTS AND STRETCHED POLYMER-CHAINS
    PINCUS, P
    [J]. MACROMOLECULES, 1976, 9 (03) : 386 - 388
  • [26] Polymer chains in confined spaces and flow-injection problems:: Some remarks
    Sakaue, T
    Raphaël, E
    [J]. MACROMOLECULES, 2006, 39 (07) : 2621 - 2628
  • [27] Folding/unfolding kinetics on a semiflexible polymer chain
    Sakaue, T
    Yoshikawa, K
    [J]. JOURNAL OF CHEMICAL PHYSICS, 2002, 117 (13) : 6323 - 6330
  • [28] Semiflexible polymer confined in closed spaces
    Sakaue, Takahiro
    [J]. MACROMOLECULES, 2007, 40 (14) : 5206 - 5211
  • [29] Nonequilibrium dynamics of polymer translocation and straightening
    Sakaue, Takahiro
    [J]. PHYSICAL REVIEW E, 2007, 76 (02):
  • [30] Translocation of double-strand DNA through a silicon oxide nanopore
    Storm, AJ
    Chen, JH
    Zandbergen, HW
    Dekker, C
    [J]. PHYSICAL REVIEW E, 2005, 71 (05):