Immune-based approaches for control of HIV infection and viral-induced immunopathogenesis

被引：2

作者：

Pinto, LA ^{[1
]}

Shearer, GM ^{[1
]}

Blazevic, V ^{[1
]}

机构：

[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

来源：

CLINICAL IMMUNOLOGY | 2000年 / 97卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/clim.2000.4913

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Due to the limited efficacy of the current antiretroviral drug regimens in completely eradicating HIV and reconstituting the immune system, AIDS research is turning toward immune-based therapy to complement highly active antiretroviral therapy. Here we review potential mechanisms of protective cellular immunity and current HIV-specific immune-based strategies and discuss the rationale for novel hypothetical immunologic approaches for modulation of host antiviral immunity. One of the mechanisms by which the immune system exerts antiviral effects is via leukocyte generation of anti-HIV factors. Recent observations in this area of research suggest that non-MN antigens can stimulate the in vitro production of anti-HIV activity by leukocytes from healthy uninfected individuals and HIV-infected patients. These findings may provide insights for the design of novel therapeutic or prophylactic approaches, which might contribute to modulating immune system control of HIV infection.

引用

页码：1 / 8

页数：8

共 96 条

[1] Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen [J].

Allen, TM ;

Vogel, TU ;

Fuller, DH ;

Mothé, BR ;

Steffen, S ;

Boyson, JE ;

Shipley, T ;

Fuller, J ;

Hanke, T ;

Sette, A ;

Altman, JD ;

Moss, B ;

McMichael, AJ ;

Watkins, DI .

JOURNAL OF IMMUNOLOGY, 2000, 164 (09) :4968-4978

[2] An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses [J].

André, P ;

Groettrup, M ;

Klenerman, P ;

de Giuli, R ;

Booth, BL ;

Cerundolo, V ;

Bonneville, M ;

Jotereau, F ;

Zinkernagel, RM ;

Lotteau, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13120-13124

[3] Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease [J].

Autran, B ;

Carcelain, G ;

Li, TS ;

Blanc, C ;

Mathez, D ;

Tubiana, R ;

Katlama, C ;

Debre, P ;

Leibowitch, J .

SCIENCE, 1997, 277 (5322) :112-116

[4] CROSS-LINKING CD4 BY HUMAN IMMUNODEFICIENCY VIRUS-GP120 PRIMES T-CELLS FOR ACTIVATION-INDUCED APOPTOSIS [J].

BANDA, NK ;

BERNIER, J ;

KURAHARA, DK ;

KURRLE, R ;

HAIGWOOD, N ;

SEKALY, RP ;

FINKEL, TH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (04) :1099-1106

[5] Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys [J].

Barouch, DH ;

Craiu, A ;

Kuroda, MJ ;

Schmitz, JE ;

Zheng, XX ;

Santra, S ;

Frost, JD ;

Krivulka, GR ;

Lifton, MA ;

Crabbs, CL ;

Heidecker, G ;

Perry, HC ;

Davies, ME ;

Xie, H ;

Nickerson, CE ;

Steenbeke, TD ;

Lord, CI ;

Montefiori, DC ;

Strom, TB ;

Shiver, JW ;

Lewis, MG ;

Letvin, NL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4192-4197

[6] Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen [J].

Bartlett, JA ;

Wasserman, SS ;

Hicks, CB ;

Dodge, RT ;

Weinhold, KJ ;

Tacket, CO ;

Ketter, N ;

Wittek, AE ;

Palker, TJ ;

Haynes, BF .

AIDS, 1998, 12 (11) :1291-1300

[7] ENHANCED ESTABLISHMENT OF A VIRUS CARRIER STATE IN ADULT CD4+ T-CELL-DEFICIENT MICE [J].

BATTEGAY, M ;

MOSKOPHIDIS, D ;

RAHEMTULLA, A ;

HENGARTNER, H ;

MAK, TW ;

ZINKERNAGEL, RM .

JOURNAL OF VIROLOGY, 1994, 68 (07) :4700-4704

[8] Induction of immune responses to HIV-1 by canarypox virus (ALVAC) HIV-1 and gp120 SF-2 recombinant vaccines in uninfected volunteers [J].

Belshe, RB ;

Gorse, GJ ;

Mulligan, MJ ;

Evans, TG ;

Keefer, MC ;

Excler, JL ;

Duliege, AM ;

Tartaglia, J ;

Cox, WI ;

McNamara, J ;

Hwang, KL ;

Bradney, A ;

Montefiori, D ;

Weinhold, KJ .

AIDS, 1998, 12 (18) :2407-2415

[9] Therapeutic vaccination with p24-VLP and zidovudine augments HIV-specific cytotoxic T lymphocyte activity in asymptomatic HIV-infected individuals [J].

Benson, EM ;

Clarkson, J ;

Law, M ;

Marshall, P ;

Kelleher, AD ;

Smith, DE ;

Patou, G ;

Stewart, GJ ;

Cooper, DA ;

Ffrench, RA .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1999, 15 (02) :105-113

[10] Efficacy testing of recombinant human immunodeficiency virus (HIV) gp160 as a therapeutic vaccine in early-stage HIV-1-infected volunteers [J].

Birx, DL ;

Loomis-Price, LD ;

Aronson, N ;

Brundage, J ;

Davis, C ;

Deyton, L ;

Garner, R ;

Gordin, F ;

Henry, D ;

Holloway, W ;

Kerkering, T ;

Luskin-Hawk, R ;

McNeil, J ;

Michael, N ;

Pierce, PF ;

Poretz, D ;

Ratto-Kim, S ;

Renzullo, P ;

Ruiz, N ;

Sitz, K ;

Smith, G ;

Tacket, C ;

Thompson, M ;

Tramont, E ;

Yangco, B ;

Yarrish, R ;

Redfield, RR .

JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (03) :881-889

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