SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma

被引：37

作者：

Chang, Dong ^{[1
]}

Ma, Kai ^{[1
]}

Gong, Min ^{[1
]}

Cui, Yong ^{[1
]}

Liu, Zhi-hua ^{[2
,3
]}

Zhou, Xiao-ge ^{[4
]}

Zhou, Chuan-nong ^{[2
,3
]}

Wang, Tian-you ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Friendship Hosp, Dept Thorac Surg, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100037, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

[4] Capital Med Univ, Beijing Friendship Hosp, Dept Pathol, Beijing 100050, Peoples R China

来源：

BIOMARKERS | 2010年 / 15卷 / 02期

关键词：

Pulmonary squamous cell carcinoma; SLP-2; tissue micro-array; prognosis; STOMATIN-LIKE PROTEIN-2; CANCER; EXPRESSION; IDENTIFICATION; PROFILE; CLONING; GROWTH; MEMBER; GENES;

D O I：

10.3109/13547500903311910

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: To investigate the role of stomatin-like protein 2 (SLP-2), a novel cancer-related gene, in pulmonary squamous cell carcinoma (PSCC) and its implications. Methods: Immunohistochemical detection of SLP-2 was performed on 96 cases of PSCC with a tissue microarray. Results: SLP-2 was overexpressed in lung cancer compared with normal lung tissue (p < 0.001). High-level SLP-2 expression was significantly correlated with distant metastasis (p = 0.025), decreased overall survival (p = 0.018) and disease-free survival (p = 0.017). SLP-2 overexpression was an independent prognostic factor in multivariate analysis using the Cox regression model (p < 0.05). Conclusion: SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in PSCC. SLP-2 could be regarded as a new significant prognostic biomarker for patients with PSCC.

引用

页码：104 / 110

页数：7

共 20 条

[1] Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study [J].

Berrino, Franco ;

De Angelis, Roberta ;

Sant, Milena ;

Rosso, Stefano ;

Lasota, Magdalena B. ;

Coebergh, Jan W. ;

Santaquilani, Mariano .

LANCET ONCOLOGY, 2007, 8 (09) :773-783

[2] Prognostic significance of stomatin-like protein 2 overexpression in laryngeal squamous cell carcinoma: clinical, histologic, and immunohistochemistry analyses with tissue microarray [J].

Cao, Wen-feng ;

Zhang, Li-yong ;

Liu, Ming-bo ;

Tang, Ping-zhang ;

Liu, Zhi-hua ;

Sun, Bao-cun .

HUMAN PATHOLOGY, 2007, 38 (05) :747-752

[3] High-level SLP-2 expression and HER-2/neu protein expression are associated with decreased breast cancer patient survival [J].

Cao, Wenfeng ;

Zhang, Bin ;

Liu, Yanxue ;

Li, Hongtao ;

Zhang, Shiwu ;

Fu, Li ;

Niu, Yun ;

Ning, Liansheng ;

Cao, Xuchen ;

Liu, Zhihua ;

Sun, Baocun .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2007, 128 (03) :430-436

[4] Prognostic significance of PTEN expression in esophageal squamous cell carcinoma from Linzhou City, a high incidence area of northern China [J].

Chang, D. ;

Wang, T.-Y. ;

Li, H.-C. ;

Wei, J.-C. ;

Song, J.-X. .

DISEASES OF THE ESOPHAGUS, 2007, 20 (06) :491-496

[5]

Cui ZM, 2007, ONCOL REP, V17, P829

[6]

Gkiozos I, 2007, ANTICANCER RES, V27, P2823

[7] Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons [J].

Goldstein, BJ ;

Kulaga, HM ;

Reed, RR .

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 2003, 4 (01) :74-82

[8] Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2 [J].

Hajek, Petr ;

Chomyn, Anne ;

Attardi, Giuseppe .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (08) :5670-5681

[9] Lung cancer adjuvant therapy [J].

Horn, Leora ;

Sandler, Alan .

CANCER JOURNAL, 2007, 13 (03) :210-216

[10]

Lu JY, 2001, INT J CANCER, V91, P288, DOI 10.1002/1097-0215(200002)9999:9999<::AID-IJC1063>3.0.CO

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