Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type

被引：202

作者：

Suzuki, R. ^{[1
]}

Suzumiya, J. ^{[2
]}

Yamaguchi, M. ^{[3
]}

Nakamura, S. ^{[4
]}

Kameoka, J. ^{[5
]}

Kojima, H. ^{[6
]}

Abe, M. ^{[7
]}

Kinoshita, T. ^{[8
]}

Yoshino, T. ^{[9
]}

Iwatsuki, K. ^{[10
]}

Kagami, Y. ^{[11
]}

Tsuzuki, T. ^{[12
]}

Kurokawa, M. ^{[13
]}

Ito, K. ^{[14
]}

Kawa, K. ^{[15
,16
]}

Oshimi, K. ^{[17
]}

机构：

[1] Nagoya Univ, Sch Med, Dept HSCT Data Management, Higashi Ku, Nagoya, Aichi 4610047, Japan

[2] Fukuoka Univ, Sch Med, Dept Internal Med, Fukuoka 81401, Japan

[3] Mie Univ, Grad Sch Med, Dept Hematol & Oncol, Tsu, Mie 514, Japan

[4] Nagoya Univ, Grad Sch Med, Dept Pathol, Nagoya, Aichi 4610047, Japan

[5] Tohoku Univ, Grad Sch Med, Dept Hematol & Rheumatol, Sendai, Miyagi 980, Japan

[6] Univ Tsukuba, Inst Clin Med, Div Hematol, Tsukuba, Ibaraki 305, Japan

[7] Fukushima Med Univ, Dept Pathol 1, Fukushima, Japan

[8] Nagoya Univ, Grad Sch Med, Dept Hematol & Oncol, Nagoya, Aichi 4610047, Japan

[9] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol, Okayama 7008530, Japan

[10] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Dermatol, Okayama 7008530, Japan

[11] Aichi Canc Ctr, Dept Hematol & Cell Therapy, Nagoya, Aichi 464, Japan

[12] Nagoya Daini Red Cross Hosp, Dept Pathol, Nagoya, Aichi, Japan

[13] Miyazaki Univ, Sch Med, Dept Dermatol, Miyazaki, Japan

[14] Niigata Univ, Grad Sch Med, Dept Dermatol, Niigata, Japan

[15] Osaka Med Ctr, Dept Pediat, Osaka, Japan

[16] Res Inst Maternal & Child Hlth, Osaka, Japan

[17] Juntendo Univ, Dept Hematol, Tokyo, Japan

来源：

ANNALS OF ONCOLOGY | 2010年 / 21卷 / 05期

关键词：

CD16; leukemia; lymphoma; natural killer cell; prognosis; COMPARATIVE GENOMIC HYBRIDIZATION; T-CELL; L-ASPARAGINASE; PHASE-I; TRANSPLANTATION; EXPRESSION; LYMPHOMA/LEUKEMIA; CLASSIFICATION; CHEMOTHERAPY; PATTERNS;

D O I：

10.1093/annonc/mdp418

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients and methods: We retrospectively analyzed 172 patients (22 with ANKL and 150 with ENKL). The ENKLs consisted of 123 nasal and 27 extranasal (16 cutaneous, 9 hepatosplenic, 1 intestinal and 1 nodal) lymphomas. Results: Complete remission rate for ENKL was 73% in stage I, but 15% in stage IV, which was consistent with that for ANKL (18%). The prognosis of ENKL was better than that of ANKL (median survival 10 versus 1.9 months, P < 0.0001) but was comparable when restricted to stage IV cases (4.0 months, P = 0.16). Multivariate analysis showed that four factors (non-nasal type, stage, performance status and numbers of extranodal involvement) were significant prognostic factors. Using these four variables, an NK prognostic index was successfully constructed. Four-year overall survival of patients with zero, one, two and three or four adverse factors were 55%, 33%, 15% and 6%, respectively. Conclusion: The current prognostic model successfully stratified patients with NK cell neoplasms with different outcomes.

引用

页码：1032 / 1040

页数：9

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