Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type

被引:202
作者
Suzuki, R. [1 ]
Suzumiya, J. [2 ]
Yamaguchi, M. [3 ]
Nakamura, S. [4 ]
Kameoka, J. [5 ]
Kojima, H. [6 ]
Abe, M. [7 ]
Kinoshita, T. [8 ]
Yoshino, T. [9 ]
Iwatsuki, K. [10 ]
Kagami, Y. [11 ]
Tsuzuki, T. [12 ]
Kurokawa, M. [13 ]
Ito, K. [14 ]
Kawa, K. [15 ,16 ]
Oshimi, K. [17 ]
机构
[1] Nagoya Univ, Sch Med, Dept HSCT Data Management, Higashi Ku, Nagoya, Aichi 4610047, Japan
[2] Fukuoka Univ, Sch Med, Dept Internal Med, Fukuoka 81401, Japan
[3] Mie Univ, Grad Sch Med, Dept Hematol & Oncol, Tsu, Mie 514, Japan
[4] Nagoya Univ, Grad Sch Med, Dept Pathol, Nagoya, Aichi 4610047, Japan
[5] Tohoku Univ, Grad Sch Med, Dept Hematol & Rheumatol, Sendai, Miyagi 980, Japan
[6] Univ Tsukuba, Inst Clin Med, Div Hematol, Tsukuba, Ibaraki 305, Japan
[7] Fukushima Med Univ, Dept Pathol 1, Fukushima, Japan
[8] Nagoya Univ, Grad Sch Med, Dept Hematol & Oncol, Nagoya, Aichi 4610047, Japan
[9] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol, Okayama 7008530, Japan
[10] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Dermatol, Okayama 7008530, Japan
[11] Aichi Canc Ctr, Dept Hematol & Cell Therapy, Nagoya, Aichi 464, Japan
[12] Nagoya Daini Red Cross Hosp, Dept Pathol, Nagoya, Aichi, Japan
[13] Miyazaki Univ, Sch Med, Dept Dermatol, Miyazaki, Japan
[14] Niigata Univ, Grad Sch Med, Dept Dermatol, Niigata, Japan
[15] Osaka Med Ctr, Dept Pediat, Osaka, Japan
[16] Res Inst Maternal & Child Hlth, Osaka, Japan
[17] Juntendo Univ, Dept Hematol, Tokyo, Japan
关键词
CD16; leukemia; lymphoma; natural killer cell; prognosis; COMPARATIVE GENOMIC HYBRIDIZATION; T-CELL; L-ASPARAGINASE; PHASE-I; TRANSPLANTATION; EXPRESSION; LYMPHOMA/LEUKEMIA; CLASSIFICATION; CHEMOTHERAPY; PATTERNS;
D O I
10.1093/annonc/mdp418
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Patients and methods: We retrospectively analyzed 172 patients (22 with ANKL and 150 with ENKL). The ENKLs consisted of 123 nasal and 27 extranasal (16 cutaneous, 9 hepatosplenic, 1 intestinal and 1 nodal) lymphomas. Results: Complete remission rate for ENKL was 73% in stage I, but 15% in stage IV, which was consistent with that for ANKL (18%). The prognosis of ENKL was better than that of ANKL (median survival 10 versus 1.9 months, P < 0.0001) but was comparable when restricted to stage IV cases (4.0 months, P = 0.16). Multivariate analysis showed that four factors (non-nasal type, stage, performance status and numbers of extranodal involvement) were significant prognostic factors. Using these four variables, an NK prognostic index was successfully constructed. Four-year overall survival of patients with zero, one, two and three or four adverse factors were 55%, 33%, 15% and 6%, respectively. Conclusion: The current prognostic model successfully stratified patients with NK cell neoplasms with different outcomes.
引用
收藏
页码:1032 / 1040
页数:9
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