Targeting the mevalonate pathway in multiple myeloma

被引：3
作者：
van der Spek, Ellen [1 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Hematol, NL-3584 CX Utrecht, Netherlands
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 03期
关键词：
Multiple myeloma; Mevalonate pathway; Plasma cell lines; FPP; GGPP; CELL-LINES; DRUG-RESISTANCE; PLASMA-CELLS; APOPTOSIS; SIMVASTATIN; INHIBITOR; SURVIVAL; PROTEIN; GERANYLGERANYLATION; FARNESYLATION;
D O I：
10.1016/j.leukres.2009.07.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：267 / 268
页数：2
相关论文
共 23 条
[11]   Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells [J].
Morgan, MA ;
Sebil, T ;
Aydilek, E ;
Peest, D ;
Ganser, A ;
Reuter, CWM .
BRITISH JOURNAL OF HAEMATOLOGY, 2005, 130 (06) :912-925
[12]   Microenvironment factors do not afford myeloma cell lines protection from simvastatin [J].
Osadchy, A ;
Drucker, L ;
Radnay, J ;
Shapira, H ;
Lishner, M .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2004, 73 (03) :183-190
[13]   The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase [J].
Schmidmaier, R ;
Baumann, P ;
Simsek, M ;
Dayyani, F ;
Emmerich, B ;
Meinhardt, G .
BLOOD, 2004, 104 (06) :1825-1832
[14]   First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma [J].
Schmidmaier, Ralf ;
Baumann, Philipp ;
Bumeder, Irmgard ;
Meinhardt, Gerold ;
Straka, Christian ;
Emmerich, Bertold .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2007, 79 (03) :240-243
[15]   Synergistic antimyeloma effects of zoledronate and simvastatin [J].
Schmidmaier, Ralf ;
Simsek, Meral ;
Baumann, Philipp ;
Emmerich, Bertold ;
Meinhardt, Gerold .
ANTI-CANCER DRUGS, 2006, 17 (06) :621-629
[16]   Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity [J].
Shipman, CM ;
Rogers, MJ ;
Apperley, JF ;
Graham, R ;
Russell, G ;
Croucher, PI .
BRITISH JOURNAL OF HAEMATOLOGY, 1997, 98 (03) :665-672
[17]   The bisphosphonate zoledronic acid induces cytotoxicity in human myeloma cell lines with enhancing effects of dexamethasone and thalidomide [J].
Ural, AU ;
Yilmaz, MI ;
Avcu, F ;
Pekel, A ;
Zerman, M ;
Nevruz, O ;
Sengul, A ;
Yalcin, A .
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2003, 78 (05) :443-449
[18]   Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels [J].
van de Donk, NWCJ ;
Kamphuis, MMJ ;
van Kessel, B ;
Lokhorst, HM ;
Bloem, AC .
BLOOD, 2003, 102 (09) :3354-3362
[19]   The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells [J].
van de Donk, NWCJ ;
Kamphuis, MMJ ;
Lokhorst, HM ;
Bloem, AC .
LEUKEMIA, 2002, 16 (07) :1362-1371
[20]   High dose Simvastatin does not reverse resistance to Vincristine, Adriamycin, and Dexamethasone (VAD) in Myeloma [J].
van der Spek, E. ;
Bloem, A. C. ;
Sinnige, H. A. ;
Lokhorst, H. M. .
HAEMATOLOGICA, 2007, 92 (12) :E130-E131
123