Impaired wound healing

被引:570
作者
Menke, Nathan B.
Ward, Kevin R.
Witten, Tarynn M.
Bonchev, Danail G.
Diegelmann, Robert F.
机构
[1] Virginia Commonwealth Univ, Med Ctr, Dept Biochem, VCU Reanimat Engn & Shock Ctr, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Med Ctr, Dept Emergency Med, VCU Reanimat Engn & Shock Ctr, Richmond, VA 23298 USA
[3] Virginia Commonwealth Univ, Ctr Study Biol Complex, VCU Reanimat Engn & Shock Ctr, Richmond, VA 23298 USA
[4] Virginia Commonwealth Univ, Dept Math, VCU Reanimat Engn & Shock Ctr, Richmond, VA 23298 USA
关键词
D O I
10.1016/j.clindermatol.2006.12.005
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Nonhealing wounds represent a significant cause of morbidity and mortality for a large portion of the population. One of the underlying mechanisms responsible for the failure of chronic wounds to heal is an out-of-control inflammatory response that is self-sustaining. Underappreciation of the inherent complexity of the healing wound has led to the failure of monotherapies, with no significant reduction in wound healing times. A model of the inflammatory profile of a nonhealing wound is one in which the equilibrium between synthesis and degradation has been shifted toward degradation. This review summarizes the current information regarding acute wound healing responses as contrasted to the delayed response characteristic of chronic wounds. In addition, some initial complexity theoretical models are proposed to define and explain the underlying pathophysiology. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:19 / 25
页数:7
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