Organ-specific autoimmunity

被引：31

作者：

King, C ^{[1
]}

Sarvetnick, N ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, IMM 23, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(97)80191-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past year has seen advances in our understanding of the mechanisms that control the expression of organ-specific autoimmunity. Attempts to develop therapeutic strategies for the prevention of autoimmune disease have largely been based on deviation of the T-cell response away from an autoaggressive, pro-inflammatory Th1 response. Manipulation of the cytokine environment at the site of antigen uptake or presentation, the source of endogenous antigen, costimulatory molecules or peptides processed and presented has yielded interesting results.

引用

页码：863 / 871

页数：9

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