Human Microbiota-Associated Mice: A Model with Challenges

被引：164

作者：

Arrieta, Marie-Claire ^{[1
,2
]}

Walter, Jens ^{[3
,4
]}

Finlay, B. Brett ^{[1
,2
,5
]}

机构：

[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada

[3] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2E1, Canada

[4] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E1, Canada

[5] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z4, Canada

来源：

CELL HOST & MICROBE | 2016年 / 19卷 / 05期

关键词：

HUMAN GUT MICROBIOTA; DIET;

D O I：

10.1016/j.chom.2016.04.014

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human microbiota-associated (HMA) mice have been used extensively in gut microbiome research. Here we discuss ecological and evolutionary aspects of the mammalian-gut microbiome interrelationship that confound the application of HMA mice, and propose experimental designs that increase the likelihood for obtaining meaningful findings.

引用

页码：575 / 578

页数：4

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