Human Microbiota-Associated Mice: A Model with Challenges

被引：156
作者：
Arrieta, Marie-Claire [1 ,2 ]
Walter, Jens [3 ,4 ]
Finlay, B. Brett [1 ,2 ,5 ]
机构：
[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada
[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada
[3] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2E1, Canada
[4] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E1, Canada
[5] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z4, Canada
来源：
CELL HOST & MICROBE | 2016年 / 19卷 / 05期
关键词：
HUMAN GUT MICROBIOTA; DIET;
D O I：
10.1016/j.chom.2016.04.014
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human microbiota-associated (HMA) mice have been used extensively in gut microbiome research. Here we discuss ecological and evolutionary aspects of the mammalian-gut microbiome interrelationship that confound the application of HMA mice, and propose experimental designs that increase the likelihood for obtaining meaningful findings.
引用
收藏
页码：575 / 578
页数：4
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