Cortical Localization of Microbleeds in Cerebral Amyloid Angiopathy: An Ultra High-Field 7T MRI Study

被引：34

作者：

Ni, Jun ^{[1
,2
,3
]}

Auriel, Eithan ^{[1
,2
]}

Martinez-Ramirez, Sergi ^{[1
,2
]}

Keil, Boris ^{[4
]}

Reed, Anne K. ^{[1
,2
]}

Fotiadis, Panagiotis ^{[1
,2
]}

Gurol, Edip Mahmut ^{[1
,2
]}

Greenberg, Steven M. ^{[1
,2
]}

Viswanathan, Anand ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, J Philip Kistler Stroke Res Ctr, Dept Neurol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] Beijing Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China

[4] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Boston, MA 02114 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 43卷 / 04期

关键词：

Cerebral amyloid angiopathy; cerebral microbleed; cortex; magnetic resonance imaging; ultra-high field; BRAIN IMAGES; ROBUST; REGISTRATION; OPTIMIZATION; HEMORRHAGE; ACCURATE; BURDEN; FSL;

D O I：

10.3233/JAD-140864

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear. We examined five consecutive patients with probable CAA and three non-demented elderly subjects with ultra-high field 7T MRI, to identify the precise location of CAA-related CMBs. In five CAA patients, 169 of a total of 170 lobar CMBs were located in cortical areas on 7T MRI, while a precise cortical versus juxtacortical localization was unable to be determined for 50/76 CMBs observed by conventional MRI. 7T MRI demonstrates that nearly all lobar CMBs are located in cortex in CAA.

引用

页码：1325 / 1330

页数：6

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