Replacement of Ala by Aib improves structuration and biological stability in thymine-based α-nucleopeptides

被引：8

作者：

Geotti-Bianchini, Piero ^{[1
,2
]}

Moretto, Alessandro ^{[2
]}

Peggion, Cristina ^{[2
]}

Beyrath, Julien ^{[1
]}

Bianco, Alberto ^{[1
]}

Formaggio, Fernando ^{[2
]}

机构：

[1] CNRS, Inst Biol Mol & Cellulaire, Lab Immunol & Chim Therapeut, F-67000 Strasbourg, France

[2] Univ Padua, Dept Chem, I-35131 Padua, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 06期

关键词：

PEPTIDE NUCLEIC-ACIDS; AMINO; DESIGN; BACKBONE; BINDING; DNA;

D O I：

10.1039/b920211k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three thymine-based nucleo-heptapeptides, each containing two nucleo-amino acids and zero, one or four Aib residues, respectively, have been synthesized. A single Aib residue is enough to promote the adoption of a helical structure in our nucleopeptides and to increase significantly their resistance towards enzymatic degradation. The insertion of four Aib residues, out of seven residues in the sequence, affords a rigid, 3(10)-helical nucleopeptide that is substantially unaffected by serum enzymes and is not cytotoxic.

引用

页码：1315 / 1321

页数：7

共 36 条

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[Anonymous], 1986, NMR of proteins and nucleic acids

[2]

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