Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development

被引：20

作者：

Chen, Liang-Fu ^{[1
]}

Zhou, Allen S. ^{[1
]}

West, Anne E. ^{[1
]}

机构：

[1] Duke Univ, Dept Neurobiol, Durham, NC USA

来源：

JOURNAL OF NEUROPHYSIOLOGY | 2017年 / 118卷 / 02期

关键词：

activity-dependent synaptic plasticity; autism; chromatin; synapse development; transcription; AUTISM SPECTRUM DISORDER; CPG-BINDING PROTEIN-2; MENTAL-RETARDATION PROTEIN; DE-NOVO MUTATIONS; RETT-SYNDROME; MEF2C HAPLOINSUFFICIENCY; BDNF TRANSCRIPTION; IN-VIVO; NEURAL DEVELOPMENT; DNA-METHYLATION;

D O I：

10.1152/jn.00067.2017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that allow nuclear transcription factors and chromatin regulatory proteins to encode aspects of specificity in experience-dependent synapse development. Here we review the evidence for the transcriptional mechanisms that sculpt activity-dependent aspects of synaptic connectivity during postnatal development and discuss how disruption of these processes is associated with aberrant brain development in autism and intellectual disability.

引用

收藏

页码：755 / 770

页数：16

相关论文

共 141 条

[11] The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition [J].

Bloodgood, Brenda L. ;

Sharma, Nikhil ;

Browne, Heidi Adlman ;

Trepman, Alissa Z. ;

Greenberg, Michael E. .

NATURE, 2013, 503 (7474) :121-+

[12] From the genetic architecture to synaptic plasticity in autism spectrum disorder [J].

Bourgeron, Thomas .

NATURE REVIEWS NEUROSCIENCE, 2015, 16 (09) :551-563

[13] Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) [J].

Brunet, A ;

Park, J ;

Tran, H ;

Hu, LS ;

Hemmings, BA ;

Greenberg, ME .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (03) :952-965

[14] MeCP2, a key contributor to neurological disease, activates and represses transcription [J].

Chahrour, Maria ;

Jung, Sung Yun ;

Shaw, Chad ;

Zhou, Xiaobo ;

Wong, Stephen T. C. ;

Qin, Jun ;

Zoghbi, Huda Y. .

SCIENCE, 2008, 320 (5880) :1224-1229

[15] MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number [J].

Chao, Hsiao-Tuan ;

Zoghbi, Huda Y. ;

Rosenmund, Christian .

NEURON, 2007, 56 (01) :58-65

[16] Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations [J].

Chapleau, Christopher A. ;

Calfa, Gaston D. ;

Lane, Meredith C. ;

Albertson, Asher J. ;

Larimore, Jennifer L. ;

Kudo, Shinichi ;

Armstrong, Dawna L. ;

Percy, Alan K. ;

Pozzo-Miller, Lucas .

NEUROBIOLOGY OF DISEASE, 2009, 35 (02) :219-233

[17] Wiring the Brain: The Biology of Neuronal Guidance [J].

Chedotal, Alain ;

Richards, Linda J. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (06)

[18] MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome [J].

Chen, Lin ;

Chen, Kaifu ;

Lavery, Laura A. ;

Baker, Steven Andrew ;

Shaw, Chad A. ;

Li, Wei ;

Zoghbi, Huda Y. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (17) :5509-5514

[19] Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice [J].

Chen, RZ ;

Akbarian, S ;

Tudor, M ;

Jaenisch, R .

NATURE GENETICS, 2001, 27 (03) :327-331

[20] Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2 [J].

Chen, WG ;

Chang, Q ;

Lin, YX ;

Meissner, A ;

West, AE ;

Griffith, EC ;

Jaenisch, R ;

Greenberg, ME .

SCIENCE, 2003, 302 (5646) :885-889

← 1 2 3 4 5 6 7 8 9 10 →