Prophylactic Radiotherapy of Hip Heterotopic Ossification: A Narrative Mini Review

被引：5

作者：

Galietta, Erika ^{[1
]}

Gaiani, Luca ^{[2
]}

Giannini, Claudio ^{[3
]}

Sambri, Andrea ^{[4
]}

Buwenge, Milly ^{[1
]}

Macchia, Gabriella ^{[5
]}

Deodato, Francesco ^{[5
]}

Cilla, Savino ^{[6
]}

Strigari, Lidia ^{[7
]}

Fiore, Michele ^{[3
]}

Cammelli, Silvia ^{[1
]}

De Paolis, Massimiliano ^{[4
]}

Morganti, Alessio Giuseppe ^{[1
]}

机构：

[1] Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, IRCCS Azienda Osped Univ Bologna,Radiat Oncol, Bologna, Italy

[2] AUSL Imola, UO Ortopedia & Traumatol, Imola, Italy

[3] IRCCS Ist Ortoped Rizzoli, Bologna, Italy

[4] IRCCS Azienda Osped Univ Bologna, UOC Ortopedia & Traumatol, Bologna, Italy

[5] Univ Cattolica Sacro Cuore, Gemelli Molise Hosp, Radiat Oncol Unit, Campobasso, Italy

[6] Univ Cattolica Sacro Cuore, Gemelli Molise Hosp, Med Phys Unit, Campobasso, Italy

[7] IRCCS Azienda Osped Univ Bologna, Med Phys Unit, Bologna, Italy

来源：

IN VIVO | 2022年 / 36卷 / 02期

关键词：

Key Words; Literature review; radiotherapy; prophylaxis; heterotopic ossification; hip; review; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; RADIATION-THERAPY; PREOPERATIVE IRRADIATION; RANDOMIZED-TRIAL; POSTOPERATIVE IRRADIATION; BONE-FORMATION; BROOKER CLASSIFICATION; DOSE IRRADIATION; RISK-FACTORS; PREVENTION;

D O I：

10.21873/invivo.12735

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Evidence on prophylactic radiotherapy (RT) in hip heterotopic ossification (HO) is sparse and conflicting. The aim of this literature review was to collect and summarize the available data on RT efficacy in preventing hip HO. The results of this review show that RT is effective in the prevention of hip HO, albeit with large variability across series. Effective prophylactic RT requires optimal treatment fields and time intervals with surgery. On the contrary, there is no clear evidence on the optimal timing (post-operative versus pre-operative RT). Comparisons between prophylactic RT and use of non-steroidal antiinflammatory drugs showed conflicting results, although most were in favor of RT. In conclusion, RT is an established prophylactic treatment for hip HO. However, optimal dose, technique and timing remain unclear, as does the usefulness of combining RT with drugs.

引用

页码：533 / 542

页数：10

共 70 条

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