Regulation of CaV1.2 current:: Interaction with intracellular molecules

被引：30

作者：

Kobayashi, Takeshi ^{[1
]}

Yamada, Yoichi ^{[1
]}

Fukao, Mitsuhiro ^{[1
]}

Tsutsuura, Masaaki ^{[1
]}

Tohse, Noritsugu ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Cellular Physiol & Signal Transduct, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2007年 / 103卷 / 04期

关键词：

Ca-V1.2; calcium; channel; current;

D O I：

10.1254/jphs.CR0070012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cav1.2 (alpha(1c)) is a pore-forming subunit of the voltage-dependent L-type calcium channel and is expressed in many tissues. The beta and alpha(2/delta) subunits are auxiliary subunits that affect the kinetics and the expression of Ca(v)1.2. In addition to the beta and alpha(2/delta) subunits, several molecules have been reported to be involved in the regulation of Ca(v)1.2 current. Calmodulm, CaBP1 (calcium-binding protein-1), CaMKII (calcium/calmodulin-dependent protein kinase II), AKAPs (A-kinase anchoring proteins), phosphatases, Caveolin-3, beta(2)-adrenergic receptor, PDZ domain proteins, sorcin, SNARE proteins, synaptotagmin, CSN5, RGK family, and AHNAK1 have all been reported to interact with Ca(v)1.2 and the beta subunit. This review focuses on the effect of these molecules on Ca(v)1.2 current.

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收藏

页码：347 / 353

页数：7

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