Synthesis of Nitro-Containing Compounds through Multistep Continuous Flow with Heterogeneous Catalysts

被引：36

作者：

Ishitani, Haruro ^{[2
]}

Saito, Yuki ^{[1
]}

Tsubogo, Tetsu ^{[2
]}

Kobayashi, Shu ^{[1
,2
]}

机构：

[1] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Sci, Green & Sustainable Chem Cooperat Lab, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 06期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

CARBON BOND FORMATION; ONE-POT SYNTHESIS; REUSABLE CATALYST; NATURAL-PRODUCTS; BASE CATALYSTS; NITROALKENES; CHEMISTRY; EFFICIENT; PRINCIPLES; FACILE;

D O I：

10.1021/acs.orglett.6b00282

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of beta-nitrostyrene derivatives and their following reactions through two-step continuous-flow protocols with heterogeneous catalysts are described. In the first step to provide beta-nitrostyrenes from aromatic aldehydes and nitromethane, readily available amino-functionalized silica gel was employed as a catalyst and gave the products continuously for at least 100 h with high selectivity. In the second step, reactions of beta-nitrostyrenes, solid bases, immobilized bases, solid acids, and chiral supported metals and nonmetals were used as catalysts, and seven kinds of nitro-containing organic compounds could be effectively synthesized through the two-step continuous-flow systems.

引用

页码：1346 / 1349

页数：4

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