Recent advances in regenerative medicine approaches for spinal cord injuries

被引：7

作者：

Hettiaratchi, Marian H. ^{[1
]}

Fuhrmann, Tobias ^{[1
]}

Shoichet, Molly S. ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada

[2] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

[3] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

CURRENT OPINION IN BIOMEDICAL ENGINEERING | 2017年 / 4卷

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

Spinal cord injury; Cell transplantation; Drug delivery; Clinical trials; Regenerative medicine;

D O I：

10.1016/j.cobme.2017.08.002

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Traumatic injury to the spinal cord leads to a loss of motor and sensory function below the level of injury. The lack of growth-associated proteins, local expression of inhibitory factors, and scar and cyst formation create an inhibitory environment in the spinal cord, which limits the regenerative capacity of endogenous or transplanted cells. Cell and drug delivery strategies, either alone or in combination, can induce changes in the local microenvironment at and around the lesion site to promote transplanted cell survival, integration, and/or endogenous repair. New biomaterial strategies also provide a platform for sustained delivery of otherwise unstable drugs.

引用

页码：40 / 49

页数：10

共 75 条

[11] Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1 [J].

Chanda, Soham ;

Ang, Cheen Euong ;

Davila, Jonathan ;

Pak, ChangHui ;

Mall, Moritz ;

Lee, Qian Yi ;

Ahlenius, Henrik ;

Jung, Seung Woo ;

Suedhof, Thomas C. ;

Wernig, Marius .

STEM CELL REPORTS, 2014, 3 (02) :282-296

[12] NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans [J].

Dickendesher, Travis L. ;

Baldwin, Katherine T. ;

Mironova, Yevgeniya A. ;

Koriyama, Yoshiki ;

Raiker, Stephen J. ;

Askew, Kim L. ;

Wood, Andrew ;

Geoffroy, Cedric G. ;

Zheng, Binhai ;

Liepmann, Claire D. ;

Katagiri, Yasuhiro ;

Benowitz, Larry I. ;

Geller, Herbert M. ;

Giger, Roman J. .

NATURE NEUROSCIENCE, 2012, 15 (05) :703-712

[13] Inducible in vivo genome editing with CRISPR-Cas9 [J].

Dow, Lukas E. ;

Fisher, Jonathan ;

O'Rourke, Kevin P. ;

Muley, Ashlesha ;

Kastenhuber, Edward R. ;

Livshits, Geulah ;

Tschaharganeh, Darjus F. ;

Socci, Nicholas D. ;

Lowe, Scott W. .

NATURE BIOTECHNOLOGY, 2015, 33 (04) :390-U98

[14] Sustained delivery of bioactive neurotrophin-3 to the injured spinal cord [J].

Elliott Donaghue, Irja ;

Tator, Charles H. ;

Shoichet, Molly S. .

BIOMATERIALS SCIENCE, 2015, 3 (01) :65-72

[15] A modified collagen scaffold facilitates endogenous neurogenesis for acute spinal cord injury repair [J].

Fan, Caixia ;

Li, Xing ;

Xiao, Zhifeng ;

Zhao, Yannan ;

Liang, Hui ;

Wang, Bin ;

Han, Sufang ;

Li, Xiaoran ;

Xu, Bai ;

Wang, Nuo ;

Liu, Sumei ;

Xue, Weiwei ;

Dai, Jianwu .

ACTA BIOMATERIALIA, 2017, 51 :304-316

[16] Overcoming inhibition in the damaged spinal cord [J].

Fawcett, JW .

JOURNAL OF NEUROTRAUMA, 2006, 23 (3-4) :371-383

[17] Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial [J].

Fehlings, M. G. ;

Nakashima, H. ;

Nagoshi, N. ;

Chow, D. S. L. ;

Grossman, R. G. ;

Kopjar, B. .

SPINAL CORD, 2016, 54 (01) :8-15

[18] Rho-ROCK Inhibition in the Treatment of Spinal Cord Injury [J].

Forgione, Nicole ;

Fehlings, Michael G. .

WORLD NEUROSURGERY, 2014, 82 (3-4) :E535-E539

[19] INCREASED LEVELS OF TRKB MESSENGER-RNA AND TRKB PROTEIN-LIKE IMMUNOREACTIVITY IN THE INJURED RAT AND CAT SPINAL-CORD [J].

FRISEN, J ;

VERGE, VMK ;

CULLHEIM, S ;

PERSSON, H ;

FRIED, K ;

MIDDLEMAS, DS ;

HUNTER, T ;

HOKFELT, T ;

RISLING, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (23) :11282-11286

[20] Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates longterm teratoma formation in a spinal cord injury model [J].

Fuehrmann, T. ;

Tam, R. Y. ;

Ballarin, B. ;

Coles, B. ;

Donaghue, I. Elliott ;

van der Kooy, D. ;

Nagy, A. ;

Tator, C. H. ;

Morshead, C. M. ;

Shoichet, M. S. .

BIOMATERIALS, 2016, 83 :23-36

← 1 2 3 4 5 6 7 8 →