Secretory control: Evidence for agonist regulation of post-fusion vesicle behaviour

1. Here, we review recent work on vesicular secretion, with a focus on the control of post-fusion events as a means of regulating secretory output. 2. In the classical model of secretion, each fused vesicle releases the entirety of its content in an all-or-none manner. In this way, the secretory output of a cell is controlled by regulating the numbers of fused vesicles. The realisation that post-fusion events can control secretory output leads to a distinct model of partial release of vesicle content. 3. Recent work shows that post-fusion events are under cellular control. Further, new data from our laboratory demonstrates agonist-dependent regulation of fusion pore behaviour. 4. We conclude that post-fusion events are not epiphenomena, but are likely an important mechanism of secretory control.