Acute Regression in Young People with Down Syndrome

被引：49

作者：

Mircher, Clotilde ^{[1
]}

Cieuta-Walti, Cecile ^{[1
]}

Marey, Isabelle ^{[1
]}

Rebillat, Anne-Sophie ^{[1
]}

Cretu, Laura ^{[1
]}

Milenko, Eliane ^{[1
]}

Conte, Martine ^{[1
]}

Sturtz, Franck ^{[1
]}

Rethore, Marie-Odile ^{[1
]}

Ravel, Aime ^{[1
]}

机构：

[1] Jerome Lejeune Inst, F-75015 Paris, France

来源：

BRAIN SCIENCES | 2017年 / 7卷 / 06期

关键词：

down syndrome; adolescence; regression; neurobiology; HIGH-RESOLUTION MRI; CHILDREN; ADOLESCENTS; DEPRESSION; DEMENTIA; ADULTS; PREVALENCE;

D O I：

10.3390/brainsci7060057

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adolescents and young adults with Down syndrome (DS) can present a rapid regression with loss of independence and daily skills. Causes of regression are unknown and treatment is most of the time symptomatic. We did a retrospective cohort study of regression cases: patients were born between 1959 and 2000, and were followed from 1984 to now. We found 30 DS patients aged 11 to 30 years old with history of regression. Regression occurred regardless of the cognitive level (severe, moderate, or mild intellectual disability (ID)). Patients presented psychiatric symptoms (catatonia, depression, delusions, stereotypies, etc.), partial or total loss of independence in activities of daily living (dressing, toilet, meals, and continence), language impairment (silence, whispered voice, etc.), and loss of academic skills. All patients experienced severe emotional stress prior to regression, which may be considered the trigger. Partial or total recovery was observed for about 50% of them. In our cohort, girls were more frequently affected than boys (64%). Neurobiological hypotheses are discussed as well as preventative and therapeutic approaches.

引用

页数：9

共 25 条

[1] Acute neuropsychiatric disorders in adolescents and young adults with Down syndrome: Japanese case reports [J].