Male-female differences in the effects of cannabinoids on sexual behavior and gonadal hormone function

被引：69

作者：

Gorzalka, Boris B. ^{[1
]}

Hill, Matthew N. ^{[2
]}

Chang, Sabrina C. H. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada

[2] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA

来源：

HORMONES AND BEHAVIOR | 2010年 / 58卷 / 01期

关键词：

Sexual behavior; Proceptivity; Receptivity; Cannabis; Cannabinoid; Endocannabinoid; THC; Testosterone; Gonadotropin; PLASMA TESTOSTERONE LEVELS; PARAVENTRICULAR NUCLEUS; LUTEINIZING-HORMONE; PENILE ERECTION; CB1; RECEPTOR; MALE RATS; ENDOCANNABINOIDS MEDIATE; GLUTAMIC-ACID; MARIHUANA USE; MARIJUANA USE;

D O I：

10.1016/j.yhbeh.2009.08.009

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The putative role of the endocannabinoid system and the effects of cannabis use in male and female sexual functioning are summarized. The influence of cannabis intake on sexual behavior and arousability appear to be dose-dependent in both men and women, although women are far more consistent in reporting facilitatory effects. Furthermore, evidence from nonhuman species indicate somewhat more beneficial than debilitating effects of cannabinoids on female sexual proceptivity and receptivity while suggesting predominantly detrimental effects on male sexual motivation and erectile functioning. Data from human and nonhuman species converge on the ephemeral nature of THC-induced testosterone decline. However, it is clear that cannabinoid-induced inhibition of male sexual behavior is independent of concurrent declines in testosterone levels. Investigations also reveal a suppression of gonadotropin release by cannabinoids across various species. Historical milestones and promising future directions in the area of cannabinoid and sexuality research are also outlined in this review. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：91 / 99

页数：9

共 127 条

[11] Cannabinoid CB1 receptors in the paraventricular nucleus and central control of penile erection: Immunocytochemistry, autoradiography and behavioral studies [J].

Castelli, M. P. ;

Piras, A. P. ;

Melis, T. ;

Succu, S. ;

Sanna, F. ;

Melis, M. R. ;

Collu, S. ;

Ennas, M. Grazia ;

Diaz, G. ;

Mackie, K. ;

Argiolas, A. .

NEUROSCIENCE, 2007, 147 (01) :197-206

[12] PSYCHOCLINICAL EFFECTS OF LONG-TERM MARIHUANA USE IN 275 INDIAN CHRONIC USERS - COMPARATIVE-ASSESSMENT OF EFFECTS IN INDIAN AND USA USERS [J].

CHOPRA, GS ;

JANDU, BS .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1976, 282 (DEC30) :95-108

[13]

CHOPRA IC, 1957, B NARCOTICS, V9, P4

[14] Endocannabinoids mediate the effects of acute stress and corticosterone on sex behavior [J].

Coddington, Emma ;

Lewis, Christine ;

Rose, James D. ;

Moore, Frank L. .

ENDOCRINOLOGY, 2007, 148 (02) :493-500

[15] 94-DAY CANNABIS STUDY [J].

COHEN, S .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1976, 282 (DEC30) :211-220

[16] ACUTE EFFECTS OF SMOKING MARIJUANA ON HORMONES, SUBJECTIVE EFFECTS AND PERFORMANCE IN MALE HUMAN-SUBJECTS [J].

CONE, EJ ;

JOHNSON, RE ;

MOORE, JD ;

ROACHE, JD .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 24 (06) :1749-1754

[17]

Crenshaw T.L., 1996, SEXUAL PHARM DRUGS A

[18] PLASMA TESTOSTERONE LEVELS IN HEALTHY MALE MARIHUANA SMOKERS [J].

CUSHMAN, P .

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE, 1975, 2 (02) :269-275

[19] CANNABIS AND DELTA-9-TETRAHYDROCANNABINOL - EFFECTS ON ELEMENTS OF SOCIAL-BEHAVIOR IN MICE [J].

CUTLER, MG ;

MACKINTOSH, JH .

NEUROPHARMACOLOGY, 1984, 23 (09) :1091-1097

[20] The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis [J].

D'Souza, DC ;

Perry, E ;

MacDougall, L ;

Ammerman, Y ;

Cooper, T ;

Wu, YT ;

Braley, G ;

Gueorguieva, R ;

Krystal, JH .

NEUROPSYCHOPHARMACOLOGY, 2004, 29 (08) :1558-1572

← 1 2 3 4 5 6 7 8 9 10 →