Antidepressant actions of ketamine: from molecular mechanisms to clinical practice

被引：114

作者：

Monteggia, Lisa M. ^{[1
]}

Zarate, Carlos, Jr. ^{[2
,3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA

[2] NIMH, Expt Therapeut & Pathophysiol Branch, NIH, Bethesda, MD 20892 USA

[3] Dept Hlth & Human Serv, Bethesda, MD USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2015年 / 30卷

基金：

美国国家卫生研究院;

关键词：

NEUROTROPHIC FACTOR; DOUBLE-BLIND; RESISTANT; ANTAGONIST; TRIAL;

D O I：

10.1016/j.conb.2014.12.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the past decade the emergence of glutamate N-methyl-D-aspartate (NMDA) receptor blockers such as ketamine as fast-acting antidepressants fostered a major conceptual advance by demonstrating the possibility of a rapid antidepressant response. This discovery brings unique mechanistic insight into antidepressant action, as there is a substantial amount of basic knowledge on glutamatergic neurotransmission and how blockade of NMDA receptors may elicit plasticity. The combination of this basic knowledge base and the growing clinical findings will facilitate the development of novel fast acting antidepressants.

引用

页码：139 / 143

页数：5

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