Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo

被引：279
作者：
Sun, YX
Schneider, A
Jung, Y
Wang, J
Dai, JL
Wang, JC
Cook, K
Osman, NI
Koh-Paige, AJ
Shim, H
Pienta, KJ
Keller, ET
McCauley, LK
Taichman, RS
机构：
[1] Univ Michigan, Sch Dent, Dept Periodont Prevent Geriatr, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Undergrad Res Opportun Program, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA
[5] Emory Univ, Winship Canc Inst, Dept Hematol Oncol, Atlanta, GA 30322 USA
[6] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA
[7] Emory Univ, Sch Med, Div Internal Med & Urol, Atlanta, GA 30322 USA
[8] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 02期
关键词：
metastasis; chemokine; marrow; prostate cancer; bone;
D O I：
10.1359/JBMR.041109
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To delineate the role of SDF-1 and CXCR4 in metastatic prostate cancer (CaP), positive correlations were established between SDF-1 levels and tumor metastasis. Neutralization of CXCR4 limited the number and the growth of intraosseous metastasis in vivo. Together, these in vivo metastasis data provide critical support that SDF-1/CXCR4 plays a role in skeletal metastasis.
引用
收藏
页码：318 / 329
页数：12
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