Kainate receptors and the induction of mossy fibre long-term potentiation

被引:39
作者
Bortolotto, ZA [1 ]
Lauri, S [1 ]
Isaac, JTR [1 ]
Collingridge, GL [1 ]
机构
[1] Univ Bristol, Sch Med Sci, Dept Anat, MRC Ctr Synapt Plast, Bristol BS8 1TD, Avon, England
关键词
synaptic plasticity; long-term potentiation; hippocampus; glutamate;
D O I
10.1098/rstb.2002.1216
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
There is intense interest in understanding the molecular mechanisms involved in long-term potentiation (LTP) in the hippocampus. Significant progress in our understanding of LTP has followed from studies of glutamate receptors, of which there are four main subtypes (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), N-methyl-D-aspartate (NMDA), mGlu and kainate). This article summarizes the evidence that the kainate subtype of glutamate receptor is an important trigger for the induction of LTP at mossy fibre synapses in the CA3 region of the hippocampus. The pharmacology of the first selective kainate receptor antagonists, in particular the GLU(K5) subunit selective antagonist LY382884, is described. LY382884 selectively blocks the induction of mossy fibre LTP, in response to a variety of different high-frequency stimulation protocols. This antagonist also inhibits the pronounced synaptic facilitation of mossy fibre transmission that occurs during high-frequency stimulation. These effects are attributed to the presence of presynaptic GLU(K5)-subunit-containing kainate receptors at mossy fibre synapses. Differences in kainate receptor-dependent synaptic facilitation of AMPA and NMDA receptor-mediated synaptic transmission are described. These data are discussed in the context of earlier reports that glutamate receptors are not involved in mossy fibre LTP and more recent experiments using kainate receptor knockout mice, that argue for the involvement of GLU(K6) but not GLU(K5) kainate receptor subunits. We conclude that activation of presynaptic GLU(K5)-containing kainate receptors is an important trigger for the induction of mossy fibre LTP in the hippocampus.
引用
收藏
页码:657 / 666
页数:10
相关论文
共 39 条
[1]  
BAHN S, 1994, J NEUROSCI, V14, P5525
[2]   INDUCTION OF LTP IN THE HIPPOCAMPUS NEEDS SYNAPTIC ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS [J].
BASHIR, ZI ;
BORTOLOTTO, ZA ;
DAVIES, CH ;
BERRETTA, N ;
IRVING, AJ ;
SEAL, AJ ;
HENLEY, JM ;
JANE, DE ;
WATKINS, JC ;
COLLINGRIDGE, GL .
NATURE, 1993, 363 (6427) :347-350
[3]   NEUROTRANSMITTER RECEPTORS .2. AMPA AND KAINATE RECEPTORS [J].
BETTLER, B ;
MULLE, C .
NEUROPHARMACOLOGY, 1995, 34 (02) :123-139
[4]  
Bleakman D, 1996, MOL PHARMACOL, V49, P581
[5]  
BLISS TVP, 1973, J PHYSIOL-LONDON, V232, P357, DOI 10.1113/jphysiol.1973.sp010274
[6]   LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF ANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH [J].
BLISS, TVP ;
LOMO, T .
JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (02) :331-356
[7]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[8]   Kainate receptors are involved in synaptic plasticity [J].
Bortolotto, ZA ;
Clarke, VRJ ;
Delany, CM ;
Parry, MC ;
Smolders, I ;
Vignes, M ;
Ho, KH ;
Miu, P ;
Brinton, BT ;
Fantaske, R ;
Ogden, A ;
Gates, M ;
Ornstein, PL ;
Lodge, D ;
Bleakman, D ;
Collingridge, GL .
NATURE, 1999, 402 (6759) :297-301
[9]   THE ROLE OF CA2+ CHANNELS IN HIPPOCAMPAL MOSSY FIBER SYNAPTIC TRANSMISSION AND LONG-TERM POTENTIATION [J].
CASTILLO, PE ;
WEISSKOPF, MG ;
NICOLL, RA .
NEURON, 1994, 12 (02) :261-269
[10]   Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons [J].
Castillo, PE ;
Malenka, RC ;
Nicoll, RA .
NATURE, 1997, 388 (6638) :182-186