Serum malondialdehyde-modified low-density lipoprotein levels on admission predict prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention

被引：12

作者：

Amioka, Naofumi ^{[1
]}

Miyoshi, Toru ^{[1
]}

Otsuka, Hiroaki ^{[1
]}

Yamada, Daisuke ^{[2
]}

Takaishi, Atsushi ^{[3
]}

Ueeda, Masayuki ^{[3
]}

Hirohata, Satoshi ^{[4
]}

Ito, Hiroshi ^{[1
]}

机构：

[1] Okayama Univ, Dept Cardiovasc Med, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan

[2] Onomichi Municipal Hosp, Dept Cardiol, Onornichi City, Japan

[3] Mitoyo Gen Hosp, Dept Cardiol, Kanonji City, Japan

[4] Okayama Univ, Dept Med Technol, Grad Sch Hlth Sci, Okayama, Japan

来源：

JOURNAL OF CARDIOLOGY | 2019年 / 74卷 / 3-4期

基金：

日本学术振兴会;

关键词：

Coronary artery disease; Percutaneous coronary intervention; Oxidized low-density lipoprotein; Prognosis; ASSOCIATION TASK-FORCE; ELEVATION MYOCARDIAL-INFARCTION; BIOCHEMICAL RISK MARKER; IN-STENT RESTENOSIS; OXIDIZED LDL; AMERICAN-COLLEGE; CARDIOVASCULAR ANGIOGRAPHY; PRACTICE GUIDELINES; MANAGEMENT; HEALTHY;

D O I：

10.1016/j.jjcc.2019.02.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a predictive marker of cardiovascular events in patients with stable angina pectoris. However, little is known about this marker in patients with acute coronary syndrome (ACS). We investigated the prognostic relevance of MDA-LDL to cardiovascular outcomes in patients with ACS. Methods: A total of 370 consecutive patients with ACS who underwent primary percutaneous coronary intervention (PCI) were enrolled from October 2009 to September 2014 at Mitoyo General Hospital. Serum MDA-LDL levels were measured at admission. The patients were divided into three tertile groups according to serum MDA-LDL levels. The primary outcomes were cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, revascularization, and heart failure requiring hospital admission. Results: MDA-LDL levels in patients with acute myocardial infarction were significantly greater than those in patients with unstable angina pectoris (mean +/- standard deviation: 133 +/- 48 U/L vs.157 +/- 69 U/L, p = 0.001). During follow-up [472 (195-920) days], 82 (22%) events occurred. Kaplan-Meier analysis showed that patients in the highest MDA-LDL tertile had the worst prognosis (log-rank, p < 0.001). Cox regression analysis showed that serum MDA-LDL levels were an independent predictor of cardiovascular events after PCI in patients with ACS, even after adjustment for age, sex, body mass index, conventional cardiovascular risk factors, other lipid biomarkers, statin use on admission, cardiac biomarkers, and presence or absence of multivessel disease (hazard ratio: 1.80 per 1 standard deviation U/L increase, 95% confidence interval: 1.07-3.16, p = 0.027). Conclusion: Serum MDA-LDL levels on admission are a significant prognostic marker in patients with ACS who undergo successful PCI. (C) 2019 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

引用

页码：258 / 266

页数：9

共 27 条

[1] Circulating malondialdehyde modified LDL is a biochemical risk marker for coronary artery disease [J].

Amaki, T ;

Suzuki, T ;

Nakamura, F ;

Hayashi, D ;

Imai, Y ;

Morita, H ;

Fukino, K ;

Nojiri, T ;

Kitano, S ;

Hibi, N ;

Yamazaki, T ;

Nagai, R .

HEART, 2004, 90 (10) :1211-1213

[2] ACC/AHA 2007 Guidelines for the Management of Patients With unstable Angina/Non-ST-Elevation Myocardial Infarction A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine [J].

Anderson, Jeffrey L. ;

Adams, Cynthia D. ;

Antman, Elliott M. ;

Bridges, Charles R. ;

Califf, Robert M. ;

Casey, Donald E., Jr. ;

Chavey, William E. ;

Fesmire, Francis M. ;

Hochman, Judith S. ;

Levin, Thomas N. ;

Lincoff, A. Michael ;

Peterson, Eric D. ;

Theroux, Pierre ;

Wenger, Nanette Kass ;

Wright, R. Scott ;

Smith, Sidney C. ;

Jacobs, Alice K. ;

Halperin, Jonathan L. ;

Hunt, Sharon A. ;

Krumholz, Harlan M. ;

Kushner, Frederick G. ;

Lytle, Bruce W. ;

Nishimura, Rick ;

Ornato, Joseph P. ;

Page, Richard L. ;

Riegel, Barbara .

CIRCULATION, 2007, 116 (07) :E148-E304

[3] 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction - A report of the American college of cardiology/American heart association task force on practice guidelines [J].

Antman, Elliott M. ;

Hand, Mary ;

Armstrong, Paul W. ;

Bates, Eric R. ;

Green, Lee A. ;

Halasyamani, Lakshmi K. ;

Hochman, Judith S. ;

Krumholz, Harlan M. ;

Lamas, Gervasio A. ;

Mullany, Charles J. ;

Pearle, David L. ;

Sloan, Michael A. ;

Smith, Sidney C., Jr. .

CIRCULATION, 2008, 117 (02) :296-329

[4] Oxidized LDL and its correlation with lipid profile and oxidative stress biomarkers in young healthy Spanish subjects [J].

Burgos Alves, Maria Isabel ;

Aviles Plaza, Francisco ;

Martinez-Tomas, Rebeca ;

Sanchez-Campillo, Maria ;

Larque, Elvira ;

Perez-Llamas, Francisca ;

Martinez Hernandez, Pedro ;

Parra Pallares, Soledad .

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2010, 66 (03) :221-227

[5] Serum levels of remnant lipoprotein cholesterol and oxidized low-density lipoprotein in patients with coronary artery disease [J].

Hiki, Makoto ;

Shimada, Kazunori ;

Ohmura, Hirotoshi ;

Kiyanagi, Takashi ;

Kume, Atsumi ;

Sumiyoshi, Katsuhiko ;

Fukao, Kosuke ;

Inoue, Nao ;

Mokuno, Hiroshi ;

Miyazaki, Tetsuro ;

Daida, Hiroyuki .

JOURNAL OF CARDIOLOGY, 2009, 53 (01) :108-116

[6] Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease [J].

Holvoet, P ;

Vanhaecke, J ;

Janssens, S ;

Van de Werf, F ;

Collen, D .

CIRCULATION, 1998, 98 (15) :1487-1494

[7] Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease [J].

Holvoet, P ;

Mertens, A ;

Verhamme, P ;

Bogaerts, K ;

Beyens, G ;

Verhaeghe, R ;

Collen, D ;

Muls, E ;

Van de Werf, F .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (05) :844-848

[8] Malondialdehyde-modified LBL as a marker of acute coronary syndromes [J].

Holvoet, P ;

Collen, D ;

Van de Werf, F .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (18) :1718-1721

[9] Oxidized LDL and the metabolic syndrome [J].

Holvoet, Paul ;

De Keyzer, Dieuwke ;

Jacobs, David R., Jr. .

FUTURE LIPIDOLOGY, 2008, 3 (06) :637-649

[10] Impact of Malondialdehyde- Modified Low-Density Lipoprotein on Tissue Characteristics in Patients With Stable Coronary Artery Disease - Integrated Backscatter-Intravascular Ultrasound Study [J].

Ikenaga, Hiroki ;

Kurisu, Satoshi ;

Kono, Shingo ;

Sumimoto, Yoji ;

Watanabe, Noriaki ;

Shimonaga, Takashi ;

Higaki, Tadanao ;

Iwasaki, Toshitaka ;

Mitsuba, Naoya ;

Ishibashi, Ken ;

Dohi, Yoshihiro ;

Fukuda, Yukihiro ;

Kihara, Yasuki .

CIRCULATION JOURNAL, 2016, 80 (10) :2173-2182

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