Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey

被引：227

作者：

Niederwieser, D. ^{[1
,2
]}

Baldomero, H. ^{[1
]}

Szer, J. ^{[3
]}

Gratwohl, M. ^{[4
]}

Aljurf, M. ^{[5
]}

Atsuta, Y. ^{[6
]}

Bouzas, L. F. ^{[7
]}

Confer, D. ^{[8
]}

Greinix, H. ^{[9
]}

Horowitz, M. ^{[10
]}

Iida, M. ^{[11
]}

Lipton, J. ^{[12
]}

Mohty, M. ^{[13
]}

Novitzky, N. ^{[14
]}

Nunez, J. ^{[15
]}

Passweg, J. ^{[1
]}

Pasquini, M. C. ^{[10
]}

Kodera, Y. ^{[16
]}

Apperley, J. ^{[17
]}

Seber, A. ^{[18
]}

Gratwohl, A. ^{[1
]}

机构：

[1] Univ Basel Hosp, Worldwide Network Blood & Marrow Transplantat WBM, Petersgraben 4, CH-4031 Basel, Switzerland

[2] Univ Hosp, Dept Hematol Oncol, Leipzig, Germany

[3] Royal Melbourne Hosp, Australasian Bone Marrow Transplant Recipient Reg, Parkville, Vic 3050, Australia

[4] Univ St Gallen, Inst Operat Res & Computat Finances, St Gallen, Switzerland

[5] King Faisal Specialist Hosp & Res Ctr, Eastern Mediterranean Blood & Marrow Transplant G, Riyadh 11211, Saudi Arabia

[6] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan

[7] Inst Nacl Canc, Latin Amer Blood & Marrow Transplant Grp LABMT, Rio De Janeiro, Brazil

[8] Natl Marrow Donor Program, Minneapolis, MN USA

[9] Med Univ Graz, Div Hematol, Graz, Austria

[10] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[11] Aichi Med Univ, Sch Med, Asian Pacific Blood & Marrow Transplant Grp APBMT, Nagakute, Aichi, Japan

[12] Princess Margaret Hosp, Canadian Blood & Marrow Transplant Grp, Toronto, ON M4X 1K9, Canada

[13] Hop St Antoine, European Blood & Marrow Transplant Grp EBMT, F-75571 Paris, France

[14] African Blood & Marrow Transplant Grp AFBMT, Johannesburg, South Africa

[15] WHO, CH-1211 Geneva, Switzerland

[16] Aichi Med Univ, Sch Med, Nagakute, Aichi, Japan

[17] Hammersmith Hosp, Dept Hematol, London, England

[18] Hosp Samaritano, Dept Pediat, Sao Paulo, Brazil

来源：

BONE MARROW TRANSPLANTATION | 2016年 / 51卷 / 06期

关键词：

ORGAN-TRANSPLANTATION; TRENDS; PERSPECTIVE; EUROPE; DONORS; SCT;

D O I：

10.1038/bmt.2016.18

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Data on 68 146 hematopoietic stem cell transplants (HSCTs) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. With transplant rates ranging from 0.1 to 1001 per 10 million inhabitants, more HSCTs were registered from unrelated 16 433 donors than related 15 493 donors. Grafts were collected from peripheral blood (66%), bone marrow (24%; mainly non-malignant disorders) and cord blood (10%). Compared with 2006, an increase of 46% total (57% allogeneic and 38% autologous) was observed. Growth was due to an increase in reporting teams (18%) and median transplant activity/team (from 38 to 48 HSCTs/team). An increase of 167% was noted in mismatched/haploidentical family HSCT. A Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis revealed the global perspective of WBMT to be its major strength and identified potential to be the key professional body for patients and authorities. The limited data collection remains its major weakness and threat. In conclusion, global HSCT grows over the years without plateauing (allogeneic>autologous) and at different rates in the four World Health Organization regions. Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood transplantation.

引用

页码：778 / 785

页数：8

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