The association between hippocampal subfield volumes in mild cognitive impairment and conversion to Alzheimer's disease

被引：37
作者：
Izzo, Jessica [1 ]
Andreassen, Ole A. [2 ,3 ]
Westlye, Lars T. [4 ]
van der Meer, Dennis [2 ,3 ,5 ]
机构：
[1] Univ Turin, Dept Psychol, Turin, Italy
[2] Univ Oslo, NORMENT, Div Mental Hlth & Addict, Oslo Univ Hosp, Oslo, Norway
[3] Univ Oslo, Inst Clin Med, Oslo, Norway
[4] Univ Oslo, Dept Psychol, Oslo, Norway
[5] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Mental Hlth & Neurosci, Maastricht, Netherlands
来源：
BRAIN RESEARCH | 2020年 / 1728卷
关键词：
Hippocampal subfields volume; Atrophy; Alzheimer's disease; Mild cognitive impairment; Diagnosis; Conversion; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; BRAIN STRUCTURES; NEURONAL LOSS; RISK-FACTORS; ATROPHY; MRI; PATTERNS; MEMORY; RECOMMENDATIONS;
D O I：
10.1016/j.brainres.2019.146591
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The hippocampal complex, strongly implicated in Alzheimer's disease (AD), is a region with functionally and structurally distinct subfields. Hippocampal subfield volumes may represent a more sensitive indicators of AD development than total hippocampal volume. We aimed to identify which subfield is the most predictive measure for an AD diagnosis and which is the most specific indicator of the conversion from mild cognitive impairment (MCI) to AD. We analyzed longitudinal structural neuroimaging data of 1350 individuals, 350 healthy controls (HC), 650 MCI and 350 AD, using FreeSurfer v6.0. The linear regression models corrected for total hippocampal volume revealed that subicular fields are the most predictive measures of AD diagnosis. Hippocampal fissure volume was significantly associated with conversion from MCI to AD. Our findings suggest that subicular hippocampal fields are most predictive of AD diagnosis, which has clinical implications for early detection. Specifically, subicular and hippocampal fissure volume measures may be used to select MCI participants who are most likely to convert in AD in clinical trials.
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