Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: Report of two cases and review of tamoxifen-associated polypoid uterine lesions

被引:25
作者
Houghton, JP
Ioffe, OB
Silverberg, SG
McGrady, B
McCluggage, WG
机构
[1] Royal Grp Hosp Trust, Dept Pathol, Belfast BT12 6BL, Antrim, North Ireland
[2] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA
[3] Med Ctr, Baltimore, MD USA
[4] Craigavon Area Hosp Trust, Dept Pathol, Craigavon, North Ireland
关键词
endometrium; metastatic breast carcinoma; polyp; tamoxifen;
D O I
10.1097/01.MP.0000062655.62606.86
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Two cases of lobular breast carcinoma metastatic to an endometrial polyp are described. Both patients had been treated with tamoxifen and presented with abnormal uterine bleeding. Histology of endometrial biopsy in both cases showed typical tamoxifen-associated endometrial polyps with focal subtle stromal infiltration by metastatic lobular breast carcinoma. This was confirmed by positive inummohistochemical staining with cytokeratin epithelial markers. Metastatic breast carcinoma may rarely involve tamoxifen-associated endometrial polyps. Because primary endometrial carcinomas may also arise within tamoxifen polyps, these should be extensively sampled. We briefly review polypoid uterine lesions that may occur secondary to tamoxifen therapy.
引用
收藏
页码:395 / 398
页数:4
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