A novel, stereoselective and practical protocol for the synthesis of 4β-aminopodophyllotoxins

被引：18

作者：

Liu, Ying-Qian ^{[1
,2
]}

Li, Lin-Hai ^{[2
]}

Yang, Liu ^{[3
]}

Li, Hong-Yu ^{[1
,2
]}

机构：

[1] Lanzhou Univ, MOE Key Lab Arid & Grassland Ecol, Sch Life Sci, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

[3] Lanzhou Jiaotong Univ, Environm & Municipal Engn Sch, Lanzhou 730000, Peoples R China

来源：

CHEMICAL PAPERS | 2010年 / 64卷 / 04期

基金：

中国国家自然科学基金;

关键词：

4; beta-aminopodophyllotoxins; anticancer drugs; Ritter reaction; ultrasound; TOPOISOMERASE-II; ANTITUMOR AGENTS; PODOPHYLLOTOXIN; DERIVATIVES; ANALOGS; 4'-O-DEMETHYLEPIPODOPHYLLOTOXIN; ETOPOSIDE; CONGENERS; MECHANISM; FACILE;

D O I：

10.2478/s11696-010-0020-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ritter reaction of podophyllotoxins with chloroacetonitrile and subsequent cleavage of the chloroacetyl group in the resulting chloroacetamide with thiourea under both classical heating and ultrasonic conditions is an efficient procedure for the synthesis of 4 beta-aminopodophyllotoxins. In general, significant improvements in the rates of reaction and yields of the sonochemical reactions relative to the classical heating reactions were observed.

引用

页码：533 / 536

页数：4

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