Microwave -assisted synthesis of 3-formyl substituted imidazo[1,2-a]pyridines

被引：20
作者：
Kusy, Damian [1 ]
Maniukiewicz, Waldemar [2 ]
Blazewska, Katarzyna M. [1 ]
机构：
[1] Lodz Univ Technol, Fac Chem, Inst Organ Chem, Zeromskiego St 116, PL-90924 Lodz, Poland
[2] Lodz Univ Technol, Fac Chem, Inst Gen & Ecol Chem, Zeromskiego St 116, PL-90924 Lodz, Poland
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 45期
关键词：
Imidazo[1,2-a]pyridine 3-carbaldehyde; Microwave heating; 2-Aminopyridines; Bromomalonaldehyde; BIOLOGICAL EVALUATION; CATALYZED SYNTHESIS; DERIVATIVES; 2-AMINOPYRIDINES; SERIES;
D O I：
10.1016/j.tetlet.2019.151244
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, metal-free method for the synthesis of 3-formyl imidazo[1,2-a]pyridines is reported. The method utilises commercially available substrates and features a broad substrate scope. The intermediate enamine was isolated and a plausible reaction mechanism proposed. (C) 2019 The Authors. Published by Elsevier Ltd.
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页数：5
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