A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity

被引：27

作者：

Gao, Qun ^{[1
,2
]}

Li, Feng ^{[1
]}

Wang, Shumin ^{[1
]}

Shen, Zhibo ^{[1
]}

Chen, Shaoyan ^{[1
]}

Ping, Yu ^{[1
]}

Qin, Guohui ^{[1
]}

Chen, Xinfeng ^{[1
]}

Yang, Li ^{[1
]}

Cao, Ling ^{[1
]}

Liu, Shasha ^{[1
]}

Zhang, Bin ^{[3
]}

Wang, Liping ^{[2
]}

Sun, Yan ^{[5
]}

Zhang, Yi ^{[1
,2
,4
,6
]}

机构：

[1] Zhengzhou Univ, Biotherapy Ctr, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Canc Ctr, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[3] Northwestern Univ, Sch Med, Dept Hematol Oncol, Chicago, IL USA

[4] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China

[5] Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China

[6] Henan Key Lab Tumor Immunol & Biotherapy, Zhengzhou 450052, Henan, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2019年 / 343卷

基金：

中国国家自然科学基金;

关键词：

Interferon-gamma; High-mobility group box 1; Dendritic cell; Cytotoxic T lymphocyte; CCL5; CXCL10; CXCL11; CCR5; CXCR3; MOBILITY GROUP BOX-1; RECEPTOR; DIFFERENTIATION; CHEMOTHERAPY; MATURATION; EFFECTOR; DISTINCT; REVEALS; DAMAGE; DEATH;

D O I：

10.1016/j.cellimm.2018.08.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and in which way the resultant interferon-gamma (IFN-gamma) further enhanced DC maturation and accumulation. It was discovered that HMGB1 was correlated with DC markers HLA-DR and CD86 in lung cancers at both mRNA and protein level. Further analyses showed HMGB1 enhanced the maturation of DCs, indicated by upregulated IFN-gamma in CD8(+) T cells. Additionally, HMGB1 increased the accumulation of DCs by promoting CCR5 and CXCR3 production. Moreover, the resultant IFN-gamma elevated the levels of HMGB1 and DC-associated chemokines, CCL5, CXCL10 and CXCL11 in tumor cells. Hence, the HMGB1-IFN-gamma cycle may represent an important mechanism underlying DC-mediated anti-tumor immune response.

引用

页数：9

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