Recent advances in animal model experimentation in autism research

被引:12
作者
Tania, Mousumi [1 ,2 ]
Khan, Md Asaduzzaman [2 ,3 ]
Xia, Kun [1 ]
机构
[1] Cent S Univ, State Key Lab Med Genet, Changsha, Hunan, Peoples R China
[2] Cent S Univ, Sch Life Sci, Dept Biochem, Changsha, Hunan, Peoples R China
[3] Luzhou Med Coll, Res Ctr Preclin Med, Luzhou, Sichuan, Peoples R China
来源
ACTA NEUROPSYCHIATRICA | 2014年 / 26卷 / 05期
基金
中国国家自然科学基金;
关键词
animal model; autism; genetic manipulations; translational research; PRODUCT PROPIONIC-ACID; MOUSE MODEL; PRENATAL EXPOSURE; VALPROIC ACID; SPECTRUM DISORDERS; BEHAVIORAL-CHANGES; SOCIAL-BEHAVIOR; MICE; RAT; ABNORMALITIES;
D O I
10.1017/neu.2013.58
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: Autism, a lifelong neuro-developmental disorder is a uniquely human condition. Animal models are not the perfect tools for the full understanding of human development and behavior, but they can be an important place to start. This review focused on the recent updates of animal model research in autism. Methods: We have reviewed the publications over the last three decades, which are related to animal model study in autism. Results: Animal models are important because they allow researchers to study the underlying neurobiology in a way that is not possible in humans. Improving the availability of better animal models will help the field to increase the development of medicines that can relieve disabling symptoms. Results from the therapeutic approaches are encouraging remarkably, since some behavioral alterations could be reversed even when treatment was performed on adult mice. Finding an animal model system with similar behavioral tendencies as humans is thus vital for understanding the brain mechanisms, supporting social motivation and attention, and the manner in which these mechanisms break down in autism. The ongoing studies should therefore increase the understanding of the biological alterations associated with autism as well as the development of knowledge-based treatments therapy for those struggling with autism. Conclusion: In this review, we have presented recent advances in research based on animal models of autism, raising hope for understanding the disease biology for potential therapeutic intervention to improve the quality of life of autism individuals.
引用
收藏
页码:264 / 271
页数:8
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