The utility of biomedical scaffolds laden with spheroids in various tissue engineering applications

被引：38

作者：

Chae, SooJung ^{[1
]}

Hong, Jiyoung ^{[1
]}

Hwangbo, Hanjun ^{[1
]}

Kim, GeunHyung ^{[1
,2
]}

机构：

[1] Sungkyunkwan Univ SKKU, Coll Biotechnol & Bioengn, Dept Biomechatron Engn, Suwon 16419, South Korea

[2] Sungkyunkwan Univ, Biomed Inst Convergence, SKKU BICS, Suwon 16419, South Korea

来源：

THERANOSTICS | 2021年 / 11卷 / 14期

基金：

新加坡国家研究基金会;

关键词：

spheroid; tissue engineering; spheroid application; scaffold-free; scaffolded; MESENCHYMAL STEM-CELLS; MULTICELLULAR SPHEROIDS; HEPATOCYTE SPHEROIDS; SUSPENSION-CULTURE; ECM INTERACTIONS; BONE DEFECTS; 3D CULTURE; REGENERATION; CARTILAGE; SIZE;

D O I：

10.7150/thno.58421

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A spheroid is a complex, spherical cellular aggregate supporting cell-cell and cell-matrix interactions in an environment that mimics the real-world situation. In terms of tissue engineering, spheroids are important building blocks that replace two-dimensional cell cultures. Spheroids replicate tissue physiological activities. The use of spheroids with/without scaffolds yields structures that engage in desired activities and replicate the complicated geometry of three-dimensional tissues. In this mini-review, we describe conventional and novel methods by which scaffold-free and scaffolded spheroids may be fabricated and discuss their applications in tissue regeneration and future perspectives.

引用

页码：6818 / 6832

页数：15

共 128 条

[1] Human liver microtissue spheroids in hollow fiber membrane bioreactor [J].