Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors

被引：39

作者：

Angeli, Andrea ^{[1
]}

Tanini, Damiano ^{[2
]}

Viglianisi, Caterina ^{[2
]}

Panzella, Lucia ^{[3
]}

Capperucci, Antonella ^{[2
]}

Menichetti, Stefano ^{[2
]}

Supuran, Claudiu T. ^{[1
]}

机构：

[1] Univ Firenze, NEUROFARBA Dept, Sez Sci Farmaceut, Via Ugo Schiff 6, I-50019 Florence, Italy

[2] Univ Firenze, Dept Chem Ugo Schiff, Via Lastruccia 3-13, I-50019 Sesto Fiorentino, Italy

[3] Univ Naples Federico II, Dept Chem Sci, Via Cintia 4, I-80126 Naples, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2017年 / 25卷 / 08期

关键词：

Carbonic anhydrase; Inhibitors; Metalloenzymes; Selenium; Diselenides; Selenides; Selenoheterocycles; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; CATALYTIC-ACTIVITY; DRUG DISCOVERY; ISOZYME-IX; TIAZOFURIN; DEHYDROGENASE; SULFONAMIDES; ANTIOXIDANT; ANALOGS;

D O I：

10.1016/j.bmc.2017.03.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of selenides, diselenides and organoselenoheterocycles were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, IV, VII and IX, involved in a variety of diseases among which glaucoma, retinitis pigmentosa, epilepsy, arthritis and tumors etc. These investigated compounds showed inhibitory action against these isoforms and some of them were selective for inhibiting the cytosolic over the membrane-bound isoforms, thus making them interesting leads for the development of isoform-selective inhibitors. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2518 / 2523

页数：6

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