Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt-Jakob disease

被引：15
作者：
Prasad, Sashank
Ko, Melissa W.
Lee, Edward B.
Gonatas, Nicholas K.
Stern, Matthew B.
Galetta, Steven
机构：
[1] Hosp Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
[2] Hosp Univ Penn, Dept Pathol, Philadelphia, PA 19104 USA
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2007年 / 253卷 / 1-2期
关键词：
Creutzfeldt-Jakob disease; prion; progressive supranuclear palsy; ophthalmoplegia;
D O I：
10.1016/j.jns.2006.11.010
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Supranuclear gaze palsies are an uncommon feature of Creutzfeldt-Jakob disease (CJD). Most reported cases of CJD with features of supranuclear gaze palsy are familial. We report 2 patients with supranuclear vertical gaze abnormalities associated with spongiform changes in the midbrain. Both patients were found to have sporadic CJD after genetic testing. Distinguishing familial from sporadic CJD in this setting has important genetic and epidemiological implications. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：69 / 72
页数：4
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