Imaging mobile zinc in biology

被引：194
作者：
Tomat, Elisa [1 ]
Lippard, Stephen J. [1 ]
机构：
[1] MIT, Dept Chem 18 498, Cambridge, MA 02139 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2010年 / 14卷 / 02期
关键词：
FLUORESCENT SENSORS; CELL BIOLOGY; IN-VITRO; ZN2+; PROBES; IONS; METALS; WATER; NEUROBIOLOGY; FLUOROPHORE;
D O I：
10.1016/j.cbpa.2009.12.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Trafficking and regulation of mobile zinc pools influence cellular functions and pathological conditions in multiple organs, including brain, pancreas, and prostate The quest for a dynamic description of zinc distribution and mobilization in live cells fuels the development of increasingly sophisticated probes Detection systems that respond to zinc binding with changes of their fluorescence emission properties have provided sensitive tools for mobile zinc imaging, and fluorescence microscopy experiments have afforded depictions of zinc distribution within live cells and tissues. Both small-molecule and protein-based fluorescent probes can address complex imaging challenges, such as analyte quantification, site-specific sensor localization, and real-time detection
引用
收藏
页码：225 / 230
页数：6
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