Long-lasting concentrations of cefovecin after subcutaneous and intramuscular administration to Patagonian sea lions (Otaria flavescens)

被引：6
作者：
Garcia-Parraga, D. [1 ]
Gilabert, J. A. [2 ]
Garcia-Pena, F. J. [3 ]
Alvaro, T. [1 ]
Ros-Rodriguez, J. M. [2 ]
Valls, M. [1 ]
Encinas, T. [2 ]
机构：
[1] Vet Serv, Oceanog, Ciudad Artes & Ciencias,Junta Murs i Vals S-N, Valencia 46013, Spain
[2] Univ Complutense Madrid, Fac Vet, Dept Pharmacol & Toxicol, Avda Puerta de Hierro S-N, E-28040 Madrid, Spain
[3] Cent Vet Lab Anim Hlth, Dept Bacteriol, Rd M-106 Km 1-4, Algete Madrid 28110, Spain
来源：
VETERINARY JOURNAL | 2016年 / 208卷
关键词：
Pharmacokinetics; Cephalosporins; Cefovecin; Patagonian sea lion; EXTENDED-SPECTRUM CEPHALOSPORIN; MARINE MAMMALS; SAFETY; EFFICACY; PHARMACOKINETICS; ABSCESSES; BACTERIA; CATS; RESISTANCE; DOGS;
D O I：
10.1016/j.tvjl.2015.09.015
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Cefovecin is a third-generation cephalosporin developed as an aqueous solution for use by the subcutaneous route in dogs and cats. This study evaluated the duration of cefovecin plasma concentrations after single intramuscular (IM) or subcutaneous (SC) injection at different doses in 10 Patagonian sea lions (Otaria flavescens). Blood samples were collected serially from the day of the injection up to 60-90 days post-injection. Plasma drug concentrations were determined by high performance liquid chromatography-UV detection and pharmacokinetic parameters were calculated by non-compartmental analysis. No reactions or side effects associated with the drug were observed in any of the studied animals. Both routes showed very similar pharmacokinetic behaviour. Elimination half-life (11.3-21.6 days, SC; 13.1-15.9 days, IM) and mean residence time (17.6-36.8 days SC; 16.5-25.4 days IM) were, in all cases and doses, considerably longer than those previously reported for any other species. Based on these findings, and preliminary data on specific pathogen sensitivity, cefovecin was found to be a very promising antimicrobial for Patagonian sea lions, in particular those that are difficult to access or that are under certain rehabilitation conditions. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：65 / 69
页数：5
相关论文
共 39 条
  • [21] Aerobic bacterial flora of the vagina and prepuce of California sea lions (Zalophus californianus) and investigation of associations with urogenital carcinoma
    Johnson, S
    Lowenstine, L
    Gulland, F
    Jang, S
    Imai, D
    Almy, F
    DeLong, R
    Gardner, I
    [J]. VETERINARY MICROBIOLOGY, 2006, 114 (1-2) : 94 - 103
  • [22] PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE-FREE ACID (EXCEDE STERILE SUSPENSION®) ADMINISTERED VIA INTRAMUSCULAR INJECTION IN WILD CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS)
    Meegan, Jenny
    Collard, Wendy T.
    Grover, G. Scott
    Pussini, Nicola
    Van Bonn, William G.
    Gulland, Frances M. D.
    [J]. JOURNAL OF ZOO AND WILDLIFE MEDICINE, 2013, 44 (03) : 714 - 720
  • [23] International co-operation on harmonisation of technical requirements for registration of veterinary medicinal products, good clinical practice, June 2000 effective 01 July 2001
    Passmore, C. A.
    Sherington, J.
    Stegemann, M. R.
    [J]. JOURNAL OF SMALL ANIMAL PRACTICE, 2008, 49 (06) : 295 - 301
  • [24] Efficacy and safety of cefovecin (Convenia™) for the treatment of urinary tract infections in dogs
    Passmore, C. A.
    Sherington, J.
    Stegemann, M. R.
    [J]. JOURNAL OF SMALL ANIMAL PRACTICE, 2007, 48 (03) : 139 - 144
  • [25] Seol B, 2011, VET ARHIV, V81, P91
  • [26] Efficacy and safety of cefovecin in treating bacterial folliculitis, abscesses, or infected wounds in dogs
    Six, Robert
    Cherni, Judy
    Chesebrough, Robert
    Cleaver, Dawn
    Lindeman, Cindy J.
    Papp, Georg
    SkogerbOe, Terry L.
    Weigel, Daniel J.
    Boucher, Joseph F.
    Stegemann, Michael R.
    [J]. JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2008, 233 (03): : 433 - 439
  • [27] Effectiveness and safety of cefovecin sodium, an extended-spectrum injectable cephalosporin, in the treatment of cats with abscesses and infected wounds
    Six, Robert
    Cleaver, Dawn M.
    Lindeman, Cindy J.
    Cherni, Judith
    Chesebrough, Robert
    Papp, Georg
    Skogerboc, Terry L.
    Weigel, Dan J.
    Boucher, Joseph F.
    Stegemann, Michael R.
    [J]. JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2009, 234 (01): : 81 - 87
  • [28] The efficacy and safety of cefovecin in the treatment of feline abscesses and infected wounds
    Stegemann, M. R.
    Sherington, J.
    Passmore, C.
    [J]. JOURNAL OF SMALL ANIMAL PRACTICE, 2007, 48 (12) : 683 - 689
  • [29] Clinical efficacy and safety of cefovecin in the treatment of canine pyoderma and wound infections
    Stegemann, M. R.
    Coati, N.
    Passmore, C. A.
    Sherington, J.
    [J]. JOURNAL OF SMALL ANIMAL PRACTICE, 2007, 48 (07) : 378 - 386
  • [30] Pharmacokinetics and pharmacodynamics of cefovecin in dogs
    Stegemann, M. R.
    Sherington, J.
    Blanchflower, S.
    [J]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2006, 29 (06) : 501 - 511
1234