Synergistic nanomedicine by combined gene and photothermal therapy

被引：234
作者：
Kim, Jinhwan [1 ]
Kim, Jihoon [2 ]
Jeong, Cherlhyun [3 ]
Kim, Won Jong [1 ,2 ]
机构：
[1] Pohang Univ Sci & Technol POSTECH, Dept Chem, 77 Cheongam Ro, Pohang 790784, South Korea
[2] Inst for Basic Sci Korea, Ctr Self Assembly & Complex, 77 Cheongam Ro, Pohang 790784, South Korea
[3] Korea Inst Sci & Technol, Ctr Theragnosis, Biomed Res Inst, Hwarang Ro 14 Gil 5, Seoul 136791, South Korea
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 98卷
关键词：
Combination therapy; Gene therapy; Photothermal therapy; Nanomedicine; Anticancer therapy; Photoswitch; NEAR-INFRARED LIGHT; STIMULI-RESPONSIVE POLYMERS; KAPPA-B P65; DRUG-DELIVERY; TEMPERATURE-DEPENDENCE; GOLD NANOPARTICLES; CANCER-THERAPY; INTRACELLULAR TRAFFICKING; SIRNA DELIVERY; GRAPHENE OXIDE;
D O I：
10.1016/j.addr.2015.12.018
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To date, various nanomaterials with the ability for gene delivery or photothermal effect have been developed in the field of biomedicine. The therapeutic potential of these nanomaterials has raised considerable interests in their use in potential next-generation strategies for effective anticancer therapy. In particular, the advancement of novel nanomedicines utilizing both therapeutic strategies of gene delivery and photothermal effect has generated much optimism regarding the imminent development of effective and successful cancer treatments. In this review, we discuss current research progress with regard to combined gene and photothermal therapy. This review focuses on synergistic therapeutic systems combining gene regulation and photothermal ablation as well as logically designed nano-carriers aimed at enhancing the delivery efficiency of therapeutic genes using the photothermal effect. The examples detailed in this review provide insight to further our understanding of combinatorial gene and photothermal therapy, thus paving the way for the design of promising nanomedicines. (C) 2015 Published by Elsevier B.V.
引用
收藏
页码：99 / 112
页数：14
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