Diastereoselective and enantioselective synthesis of 4′-aza analogues of 2′,3′-dideoxynucleosides

被引：41

作者：

Chiacchio, U

Rescifina, A

Corsaro, A

Pistarà, V

Romeo, G

Romeo, R

机构：

[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

[2] Univ Messina, Dipartimento Farmaco Chim, I-98100 Messina, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(00)00160-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A diastereo- and enantioselective synthesis of 4'-aza analogues of 2',3'-dideoxynucleosides has been designed by the strategy of the 1,3-dipolar cycloaddition reaction of a Vasella-type nitrone. The reaction leads to (1'R)- and (1'S)-4'-aza analogues of 2',3'-dideoxythimidine and fluorouridine, in enantiomerically pure forms. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：2045 / 2048

页数：4

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