Fatty acid binding proteins - The evolutionary crossroads of inflammatory and metabolic responses

被引：223

作者：

Makowski, L ^{[1
]}

Hotamisligil, GS ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA USA

来源：

JOURNAL OF NUTRITION | 2004年 / 134卷 / 09期

关键词：

fatty acid binding protein (FABP); Metabolic Syndrome; inflammation; obesity; insulin resistance;

D O I：

10.1093/jn/134.9.2464S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell's delicate lipid balance. Yet they fail when faced with metabolic or inflammatory stress, turning the cytosol into an inhospitable environment with less than ideal outcomes. This review will focus on how FABPs direct lipid traffic and simultaneously control inflammatory and metabolic pathways under the pressures of the Metabolic Syndrome.

引用

页码：2464S / 2468S

页数：5

共 56 条

[1] Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm [J].

Abumrad, N ;

Coburn, C ;

Ibrahimi, A .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1999, 1441 (01) :4-13

[2]

[Anonymous], DIABETES MELLITUS FU

[3] PPARγ, the ultimate thrifty gene [J].

Auwerx, J .

DIABETOLOGIA, 1999, 42 (09) :1033-1049

[4] Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization [J].

Binas, B ;

Danneberg, H ;

McWhir, J ;

Mullins, L ;

Clark, AJ .

FASEB JOURNAL, 1999, 13 (08) :805-812

[5] Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia [J].

Boord, JB ;

Maeda, K ;

Makowski, L ;

Babaev, VR ;

Fazio, S ;

Linton, MF ;

Hotamisligil, GS .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (10) :1686-1691

[6] 15-deoxy-Δ 12,14-prostaglandin J2 inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit [J].

Cernuda-Morollón, E ;

Pineda-Molina, E ;

Cañada, FJ ;

Pérez-Sala, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) :35530-35536

[7] Preadipocyte conversion to macrophage -: Evidence of plasticity [J].

Charrière, G ;

Cousin, B ;

Arnaud, E ;

André, M ;

Bacou, F ;

Pénicaud, L ;

Casteilla, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) :9850-9855

[8] Nuclear receptors and lipid physiology: Opening the X-files [J].

Chawla, A ;

Repa, JJ ;

Evans, RM ;

Mangelsdorf, DJ .

SCIENCE, 2001, 294 (5548) :1866-1870

[9]

Coe NR, 1999, J LIPID RES, V40, P967

[10] Physiological properties and functions of intracellular fatty acid-binding proteins [J].

Coe, NR ;

Bernlohr, DA .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1998, 1391 (03) :287-306

← 1 2 3 4 5 6 →