The Advance of YAP Regulating Epithelial-mesenchymal Transition in Cells

被引:0
作者
Su Guan-Yue [1 ]
Yu Hong-Chi [2 ]
Huang Wen-Wen [1 ]
Wang Ren-Yi [3 ]
Hu Yi-Qing [3 ]
Shen Yang [1 ]
Wang Yun-Bing [2 ]
Liu Xiao-Heng [1 ]
机构
[1] Sichuan Univ, Inst Biomed Engn, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Sichuan, Peoples R China
[2] Natl Engn Res Ctr Biomat, Chengdu 610065, Sichuan, Peoples R China
[3] Sichuan Univ, West China Sch Med, Chengdu 610041, Sichuan, Peoples R China
基金
中国国家自然科学基金;
关键词
YAP; EMT; tumor metastasis; tissue development; organ fibrosis; AMPK-MEDIATED REGULATION; HIPPO PATHWAY; PROMOTES; ANGIOMOTIN; EMT; TAZ; PROLIFERATION; INVASION; YAP/TAZ; CHEMORESISTANCE;
D O I
10.16476/j.pibb.2017.0457
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epithelial-mesenchymal transition (EMT) is a process by which epithelial-derived cells experience phenotypic transformation, gain mesenchymal-like cell phenotype under the condition of various physical and chemical factors. Many signaling molecules participate in regulating EMT during the process of embryo development, organ regeneration and tumor development. As the downstream effector of Hippo signal pathway, the role of YAP in EMT has been widely studied. It plays a dominant role in gene expression to control the cell proliferation and apoptosis, and organ development and regeneration. In addition, increasing evidences demonstrate that activity of YAP is closely related to tumor migration and invasion, along with the occurrence of EMT. Here, we reviewed the roles of YAP in EMT in tissue development, organ fibrosis and tumor development, and the progress of related molecular mechanisms, which is expected to broaden a new prospective for EMT studies and provide new molecular targets and diagnostic strategies for the treatment of related diseases.
引用
收藏
页码:705 / 713
页数:9
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