Iron oxide nanoparticle surface decorated with cRGD peptides for magnetic resonance imaging of brain tumors

被引：41

作者：

Richard, Sophie ^{[1
,2
]}

Boucher, Marianne ^{[3
]}

Lalatonne, Yoann ^{[4
,5
]}

Meriaux, Sebastien ^{[3
]}

Motte, Laurence ^{[5
]}

机构：

[1] CNRS, UMR 7057, Lab Matiere & Syst Complexes MSC, F-75205 Paris 05, France

[2] Univ Paris Diderot, F-75205 Paris 05, France

[3] CEA DRF I2BM NeuroSpin, Unite Imagerie Resonance Magnet & Spectroscopie, F-91191 Gif Sur Yvette, France

[4] Hop Avicenne, AP HP, Serv Med Nucl, F-93009 Bobigny, France

[5] Univ Paris 13, UFR SMBH, Lab Vasc Translat Sci, U1148,Sorbonne Paris Cite,INSERM, F-93017 Bobigny, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2017年 / 1861卷 / 06期

关键词：

Glioblastoma; Iron oxide nanoparticle; MRI contrast agent; cRGD; Targeting; TARGETING ALPHA(V)BETA(3) INTEGRINS; CANCER NANOTECHNOLOGY; STEM-CELLS; THERAPY; MICROENVIRONMENT; OPPORTUNITIES; CHEMISTRY; ANTIBODY; RGD;

D O I：

10.1016/j.bbagen.2016.12.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this article, a specific targeting Magnetic Resonance Imaging (MRI) nanoplatform, composed by iron oxide nanoparticle (NP) with cRGD peptides as targeting agent onto NP surface, is explored for the diagnosis of brain tumors by MRI using intracranial U87MG mice xenograft tumor. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editor: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1515 / 1520

页数：6

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