Regenerating the damaged central nervous system

被引：633
作者：
Horner, PJ [1 ]
Gage, FH [1 ]
机构：
[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA
来源：
NATURE | 2000年 / 407卷 / 6807期
关键词：
D O I：
10.1038/35039559
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
It is self-evident that the adult mammalian brain and spinal cord do not regenerate after injury, but recent discoveries have forced a reconsideration of this accepted principle. Advances in our understanding of how the brain develops have provided a rough blueprint for how we may bring about regeneration in the damaged brain. Studies in developmental neurobiology, intracellular signalling and neuroimmunology are bringing the regeneration field closer to success. Notwithstanding these advances, clear and indisputable evidence for adult functional regeneration remains to be shown.
引用
收藏
页码：963 / 970
页数：8
相关论文
共 97 条
[11]   Neuroprotective effects of interleukin-10 following excitotoxic spinal cord injury [J].
Brewer, KL ;
Bethea, JR ;
Yezierski, RP .
EXPERIMENTAL NEUROLOGY, 1999, 159 (02) :484-493
[12]   Embryonic stem cell-derived glial precursors:: A source of myelinating transplants [J].
Brüstle, O ;
Jones, KN ;
Learish, RD ;
Karram, K ;
Choudhary, K ;
Wiestler, OD ;
Duncan, ID ;
McKay, RDG .
SCIENCE, 1999, 285 (5428) :754-756
[13]   Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice [J].
Bush, TG ;
Puvanachandra, N ;
Horner, CH ;
Polito, A ;
Ostenfeld, T ;
Svendsen, CN ;
Mucke, L ;
Johnson, MH ;
Sofroniew, MV .
NEURON, 1999, 23 (02) :297-308
[14]   Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism [J].
Cai, DM ;
Shen, YJ ;
De Bellard, M ;
Tang, S ;
Filbin, MT .
NEURON, 1999, 22 (01) :89-101
[15]  
Cajal RS., 1928, DEGENERATION REGENER
[16]  
CARONI P, 1988, PROG BRAIN RES, V78, P363
[17]   2 MEMBRANE-PROTEIN FRACTIONS FROM RAT CENTRAL MYELIN WITH INHIBITORY PROPERTIES FOR NEURITE GROWTH AND FIBROBLAST SPREADING [J].
CARONI, P ;
SCHWAB, ME .
JOURNAL OF CELL BIOLOGY, 1988, 106 (04) :1281-1288
[18]   Bcl-2 promotes regeneration of severed axons in mammalian CNS [J].
Chen, DF ;
Schneider, GE ;
Martinou, JC ;
Tonegawa, S .
NATURE, 1997, 385 (6615) :434-439
[19]   Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1 [J].
Chen, MS ;
Huber, AB ;
van der Haar, ME ;
Frank, M ;
Schnell, L ;
Spillmann, AA ;
Christ, F ;
Schwab, ME .
NATURE, 2000, 403 (6768) :434-439
[20]   Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function [J].
Cheng, H ;
Cao, YH ;
Olson, L .
SCIENCE, 1996, 273 (5274) :510-513
12345678910