Obesity and Breast Cancer: Progress to Understanding the Relationship

被引：91

作者：

Brow, Kristy A. ^{[1
,2
]}

Simpson, Evan R. ^{[1
,3
]}

机构：

[1] Prince Henrys Inst, Monash Med Ctr, Clayton, Vic 3168, Australia

[2] Monash Univ, Dept Physiol, Melbourne, Vic 3168, Australia

[3] Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3168, Australia

来源：

CANCER RESEARCH | 2010年 / 70卷 / 01期

基金：

英国医学研究理事会;

关键词：

RISK; METFORMIN; LEPTIN; KINASE; TARGET;

D O I：

10.1158/0008-5472.CAN-09-2257

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiological evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase (AMPK) is recognized to be a master regulator of energy homeostasis. One of its actions is to phosphorylate and inhibit the actions of cAMP-responsive element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2). In postmenopausal women, the CREB-dependent regulation of aromatase is a crucial determinant of breast tumor formation through local production of estrogens. We report here that the regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk. Cancer Res; 70(1); 4-7. (C) 2010 AACR.

引用

页码：4 / 7

页数：4

共 14 条

[1] Subcellular Localization of Cyclic AMP-Responsive Element Binding Protein-Regulated Transcription Coactivator 2 Provides a Link between Obesity and Breast Cancer in Postmenopausal Women [J].

Brown, Kristy A. ;

McInnes, Kerry J. ;

Hunger, Nicole I. ;

Oakhiil, Jonathan S. ;

Steinberg, Gregory R. ;

Simpson, Evan R. .

CANCER RESEARCH, 2009, 69 (13) :5392-5399

[2]

Bulun S E, 1994, J Clin Endocrinol Metab, V78, P1616, DOI 10.1210/jc.78.2.1616

[3] Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line [J].

Catalano, S ;

Marsico, S ;

Giordano, C ;

Mauro, L ;

Rizza, P ;

Panno, ML ;

Andò, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (31) :28668-28676

[4] Is it Time to Test Metformin in Breast Cancer Clinical Trials? [J].

Cazzaniga, Massimiliano ;

Bonanni, Bernardo ;

Guerrieri-Gonzaga, Aliana ;

Decensi, Andrea .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (03) :701-705

[5] Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells [J].

Dieudonne, Marie-Noelle ;

Bussiere, Marianne ;

Dos Santos, Esther ;

Leneveu, Marie-Christine ;

Giudicelli, Yves ;

Pecquery, Rene .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 345 (01) :271-279

[6] Metformin and reduced risk of cancer in diabetic patients [J].

Evans, JMM ;

Donnelly, LA ;

Emslie-Smith, AM ;

Alessi, DR ;

Morris, AD .

BMJ-BRITISH MEDICAL JOURNAL, 2005, 330 (7503) :1304-1305

[7] Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase [J].

Jenne, DE ;

Reimann, H ;

Nezu, J ;

Friedel, W ;

Loff, S ;

Jeschke, R ;

Müller, D ;

Back, W ;

Zimmer, M .

NATURE GENETICS, 1998, 18 (01) :38-44

[8] The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism [J].

Koo, SH ;

Flechner, L ;

Qi, L ;

Zhang, XM ;

Screaton, RA ;

Jeffries, S ;

Hedrick, S ;

Xu, W ;

Boussouar, F ;

Brindle, P ;

Takemori, H ;

Montminy, M .

NATURE, 2005, 437 (7062) :1109-1114

[9] AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer [J].

Motoshima, Hiroyuki ;

Goldstein, Barry J. ;

Igata, Motoyuki ;

Araki, Eiichi .

JOURNAL OF PHYSIOLOGY-LONDON, 2006, 574 (01) :63-71

[10] Estrogen - the good, the bad, and the unexpected [J].

Simpson, ER ;

Misso, M ;

Hewitt, KN ;

Hill, RA ;

Boon, WC ;

Jones, ME ;

Kovacic, A ;

Zhou, J ;

Clyne, CD .

ENDOCRINE REVIEWS, 2005, 26 (03) :322-330

← 1 2 →