Variation in FTO contributes to childhood obesity and severe adult obesity

被引：1540

作者：

Dina, Christian ^{[1
]}

Meyre, David

Gallina, Sophie

Durand, Emmanuelle

Koerner, Antje

Jacobson, Peter

Carlsson, Lena M. S.

Kiess, Wieland

Vatin, Vincent

Lecoeur, Cecile

Delplanque, Jerome

Vaillant, Emmanuel

Pattou, Francois

Ruiz, Juan

Weill, Jacques

Levy-Marchal, Claire

Horber, Fritz

Potoczna, Natascha

Hercberg, Serge

Le Stunff, Catherine

Bougneres, Pierre

Kovacs, Peter

Marre, Michel

Balkau, Beverley

Cauchi, Stephane

Chevre, Jean-Claude

Froguel, Philippe

机构：

[1] Inst Pasteur, CNRS 8090, Inst Biol, F-59019 Lille, France

[2] Univ Leipzig, Univ Hosp Children & Adolescents, D-7010 Leipzig, Germany

[3] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, S-40020 Gothenburg, Sweden

[4] Univ Lille 2, INSERM, U859, F-59045 Lille, France

[5] CHU Vaudois, Lausanne, Switzerland

[6] Jeanne Flandre Hosp, Paediat Endocrine Unit, Lille, France

[7] Hop Robert Debre, INSERM, U690, F-75019 Paris, France

[8] Klin Lindberg, Winterthur, Switzerland

[9] INRA, U1125, Bobigny, France

[10] INSERM, U557, Bobigny, France

[11] CNAM, EA3200, Paris, France

[12] Univ Paris 13, Paris, France

[13] CRNH, Paris, France

[14] Univ Paris 05, St Vincent Paul Hosp, Dept Pediat Endocrinol, F-75005 Paris, France

[15] Univ Paris 05, St Vincent Paul Hosp, INSERM U561, F-75005 Paris, France

[16] Univ Leipzig, Dept Internal Med 2, D-7010 Leipzig, Germany

[17] Univ Leipzig, Interdisciplinary Ctr Clin Res, D-7010 Leipzig, Germany

[18] Hop Bichat Claude Bernard, AP HP, Dept Diabetol, F-75877 Paris 18, France

[19] INSERM, U780, IFR69, Villejuif, France

[20] Univ Paris Sud, Villejuif, France

[21] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, London SW7 2AY, England

来源：

NATURE GENETICS | 2007年 / 39卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ng2048

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at- risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

引用

页码：724 / 726

页数：3

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