Contrasting Timing of Virological Relapse After Discontinuation of Tenofovir or Entecavir in Hepatitis B e Antigen-Negative Patients

被引：38

作者：

zu Siederdissen, Christoph Hoener ^{[1
]}

Hui, Aric Josun ^{[4
]}

Sukeepaisamjaroen, Wattana ^{[5
]}

Tangkijvanich, Pisit ^{[6
]}

Su, Wei Wen ^{[7
,8
]}

Guillen Nieto, Gerardo Enrique ^{[9
]}

Gineste, Paul ^{[10
]}

Nitcheu, Josianne ^{[10
]}

Crabe, Sandrine ^{[10
]}

Stepien, Sandrine ^{[13
]}

Manns, Michael P. ^{[1
,2
]}

Trepo, Christian ^{[11
,12
]}

Wedemeyer, Heiner ^{[1
,2
,3
]}

Cornberg, Markus ^{[1
,2
]}

机构：

[1] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany

[2] German Ctr Infect Res, Hannover, Germany

[3] Univ Clin Essen, Dept Gastroenterol & Hepatol, Essen, Germany

[4] Alice Ho Miu Ling Nethersole Hosp, Hong Kong, Hong Kong, Peoples R China

[5] Khon Kaen Univ, Khon Kaen, Thailand

[6] Chulalongkorn Univ, Ctr Excellence Hepatitis & Liver Canc, Bangkok, Thailand

[7] Changhua Christian Hosp, Dept Gastroenterol, Changhua, Taiwan

[8] Chung Shan Med Univ, Sch Med, Taichung, Taiwan

[9] Ctr Ingn Genet & Biotecnol, Havana, Cuba

[10] Abivax, Paris, France

[11] Groupement Hosp Nord, Hosp Civils Lyon, Dept Hepatol, Lyon, France

[12] Lyon Univ, Lyon, France

[13] Georges Inst, Sydney, NSW, Australia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷 / 09期

关键词：

Virological relapse; nucleos(t)ide discontinuation; tenofovir; entecavir; HBeAg negative hepatitis B virus infection; GUIDELINES; THERAPY;

D O I：

10.1093/infdis/jiy350

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stopping long-term nucleos(t)ide analogue therapy increases hepatitis B virus (HBV) surface antigen (HBsAg) loss rates in HBV e antigen (HBeAg)-negative patients. Viral rebound may induce immune responses facilitating functional cure. We analyzed which factors are associated with timing of virological relapse in 220 Asian HBeAg-negative patients from the prospective ABX203 vaccine study. Unexpectedly, only the type of antiviral therapy was significantly associated with early virological relapse, defined as an HBV DNA load of >2000 IU/mL until week 12, and relapse occurred earlier in patients treated with tenofovir versus those treated with entecavir (median time, 6 vs 24 weeks; P < .0001). This should be considered for future trials and monitoring of patients after treatment discontinuation.

引用

页码：1480 / 1484

页数：5

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