Investigations of process parameters during dissolution studies of drug loaded 3D printed tablets

被引：18

作者：

Sharma, Varun ^{[1
]}

Shaik, Khaja Moinuddin ^{[2
]}

Choudhury, Archita ^{[2
]}

Kumar, Pramod ^{[2
]}

Kala, Prateek ^{[3
]}

Sultana, Yasmin ^{[4
]}

Shukla, Rahul ^{[5
]}

Kumar, Dalip ^{[6
]}

机构：

[1] IIT Roorkee, Dept Mech & Ind Engn, Roorkee 247667, Uttarakhand, India

[2] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut Anal, Gauhati 781125, Assam, India

[3] BITS Pilani, Dept Mech Engn, Pilani, Rajasthan, India

[4] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi, India

[5] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, Lucknow, Uttar Pradesh, India

[6] BITS Pilani, Dept Chem, Pilani, Rajasthan, India

来源：

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE | 2021年 / 235卷 / 05期

关键词：

FDM; PVA; dissolution; 3D printing; tablets;

D O I：

10.1177/0954411921993582

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The present research paper attempts to study the effect of different process parameters on the dissolution rate during 3D printed tablets. Three-dimensional printing has the potential of serving tailored made tablets to cater personalized drug delivery systems. Fluorescein loaded PVA filaments through impregnation route was used to fabricate tablets based on Taguchi based design of experimentation using Fused Deposition Modelling (FDM). The effect of print speed, infill percentage and layer thickness were analyzed to study the effect on rate of dissolution. Infill percentage followed by print speed were found to be critical parameters affecting dissolution rate. The data analysis provided an insight into the study of interaction among different 3D printing parameters to develop an empirical relation for percentage release of the drug in human body.

引用

页码：523 / 529

页数：7

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