Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality

被引:285
作者
Romero-Corral, Abel [1 ]
Somers, Virend K. [1 ]
Sierra-Johnson, Justo [2 ]
Korenfeld, Yoel [1 ]
Boarin, Simona [3 ]
Korinek, Josef [1 ]
Jensen, Michael D. [1 ]
Parati, Gianfranco [3 ]
Lopez-Jimenez, Francisco [1 ]
机构
[1] Mayo Clin, Coll Med, Rochester, MN 55905 USA
[2] Karolinska Inst, Dept Med, Atherosclerosis Res Unit, S-10401 Stockholm, Sweden
[3] Ist Auxol Italiano San Luca, San Luca, Italy
关键词
Normal weight obesity; Body fat; Metabolic syndrome; Cardiovascular risk factor; Mortality; Cardiovascular mortality; BODY-MASS INDEX; AMERICAN-HEART-ASSOCIATION; MYOCARDIAL-INFARCTION; SCIENTIFIC STATEMENT; METABOLIC SYNDROME; UNITED-STATES; OVERWEIGHT; DISEASE; FAT; NUTRITION;
D O I
10.1093/eurheartj/ehp487
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We hypothesized that subjects with a normal body mass index (BMI), but high body fat (BF) content [normal weight obesity (NWO)], have a higher prevalence of cardiometabolic dysregulation and are at higher risk for cardiovascular (CV) mortality. We analysed 6171 subjects > 20 years of age from the Third National Health and Nutrition Examination Survey (NHANES III) and the NHANES III mortality study, whose BMI was within the normal range (18.5-24.9 kg/m(2)), and who underwent a complete evaluation that included body composition assessment, blood measurements, and assessment of CV risk factors. Survival information was available for > 99% of the subjects after a median follow-up of 8.8 years. We divided our sample using sex-specific tertiles of BF%. The highest tertile of BF (> 23.1% in men and > 33.3% in women) was labelled as NWO. When compared with the low BF group, the prevalence of metabolic syndrome in subjects with NWO was four-fold higher (16.6 vs. 4.8%, P < 0.0001). Subjects with NWO also had higher prevalence of dyslipidaemia, hypertension (men), and CV disease (women). After adjustment, women with NWO showed a significant 2.2-fold increased risk for CV mortality (HR = 2.2; 95% CI, 1.03-4.67) in comparison to the low BF group. Normal weight obesity, defined as the combination of normal BMI and high BF content, is associated with a high prevalence of cardiometabolic dysregulation, metabolic syndrome, and CV risk factors. In women, NWO is independently associated with increased risk for CV mortality.
引用
收藏
页码:737 / 746
页数:10
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