Novel antiviral effect of lithium chloride on mammalian orthoreoviruses in vitro

被引：9
作者：
Chen, Ye [1 ]
Kong, Deyang [2 ]
Cai, Gengyuan [1 ]
Jiang, Zhiguo [1 ]
Jiao, Yiren [1 ]
Shi, Yuzhen [1 ]
Li, Huaqin [1 ]
Wang, Chong [1 ]
机构：
[1] South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 1, Dept Nephrol, 23 Youzheng St, Harbin 150001, Peoples R China
来源：
MICROBIAL PATHOGENESIS | 2016年 / 93卷
基金：
中国国家自然科学基金;
关键词：
LiCl; Reovirus; Antiviral effect; Replication; INFECTIOUS-BRONCHITIS VIRUS; HERPES-SIMPLEX VIRUS; REOVIRUS GENOME; CELLS; DIAMMONIUM; DISEASE; ORIGIN; CHILD; PIGS;
D O I：
10.1016/j.micpath.2016.01.023
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Reovirus not only causes considerable economic loss in the swine industry of the United States and other countries, but also threatens the public health due to its zoonotic potential. According to previous reports, LiCl has antiviral activity against a number of viruses. The inhibitory effects of LiCl on reovirus life cycle in Vero cells were evaluated. The unpaired t-test and one-way ANOVA were used to analyze the differences between experimental groups. We first found that LiCl treatment significantly inhibited reovirus replication in a dose-dependent manner. Furthermore, we found that this antiviral activity of LiCl targets the early stage of viral replication. LiCl could be a potential drug against reovirus infection. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：152 / 157
页数：6
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