Asporin Expression on Stromal Cells and/or Cancer Cells Might Be A Useful Prognostic Marker in Patients with Diffuse-Type Gastric Cancer

被引：7

作者：

Yashiro, Masakazu ^{[1
,2
,3
]}

Hasegawa, Tsuyoshi ^{[1
,2
]}

Yamamoto, Yurie ^{[1
,3
]}

Tsujio, Gen ^{[1
,2
]}

Nishimura, Sadaaki ^{[1
,2
]}

Sera, Tomohiro ^{[1
,2
]}

Sugimoto, Atsushi ^{[1
,2
]}

Kushiyama, Shuhei ^{[1
,2
]}

Kasashima, Hiroaki ^{[1
,2
]}

Fukuoka, Tatsunari ^{[1
,2
,3
]}

Sakurai, Katsunobu ^{[2
]}

Toyokawa, Takahiro ^{[2
]}

Kubo, Naoshi ^{[2
]}

Ohira, Masaichi ^{[2
]}

机构：

[1] Osaka City Univ, Mol Oncol & Therapeut, Grad Sch Med, Osaka, Japan

[2] Osaka City Univ, Dept Gastroenterol Surg, Grad Sch Med, Osaka, Japan

[3] Osaka City Univ, Canc Ctr Translat Res, Grad Sch Med, Osaka, Japan

来源：

EUROPEAN SURGICAL RESEARCH | 2021年 / 62卷 / 01期

关键词：

Asporin; Stromal cells; Gastric cancer; PROSTATE-CANCER; INVASION; GROWTH; FIBROBLASTS; MIGRATION; SUSCEPTIBILITY; IDENTIFICATION; PROLIFERATION; POLYMORPHISM; MECHANISMS;

D O I：

10.1159/000515458

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Asporin (ASPN), a member of the proteoglycan family, has been shown to have a close correlation with cancer progression. It is not known whether ASPN is an oncogenic driver or a tumor suppressor in human gastric cancer. We sought herein to determine the relationship between ASPN expression and clinicopathological features of gastric cancer. Patients and Methods: A total of 296 gastric cancer patients (diffuse type, n = 144; intestinal type, n = 152) were enrolled. The ASPN expression level in each case was analyzed by immunohistochemistry. Results: ASPN was mainly found on stromal cells, especially on fibroblasts in tumor stroma, i.e., cancer-associated fibroblasts. The ASPN expression on either cancer cells or stromal cells was significantly high in macroscopic scirrhous-type tumors (p < 0.001) and histologically abundant stroma-type tumors (p < 0.001). Interestingly, a Kaplan-Meier survival curve of the 144 cases of diffuse-type gastric cancer revealed a significantly poorer prognosis in patients with ASPN-positive expression (p = 0.043; log rank) compared to those with ASPN-negative expression, but the prognoses were not significantly different in these subgroups of the 152 cases of intestinal-type gastric cancer. A multivariate analysis with respect to overall survival showed that ASPN expression on stromal cells and/or cancer cells was significantly correlated with overall survival in patients with diffuse-type gastric cancer (p = 0.041). Conclusion: In gastric cancer, ASPN was expressed mainly on stromal cells and partially on cancer cells. ASPN expression on stromal cells and/or cancer cells might be a useful prognostic marker in patients with diffuse-type gastric cancer.

引用

页码：53 / 60

页数：8

共 27 条

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