Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: 10-Color flow cytometry diagnosis and HyperCVAD therapy

被引：39

作者：

Deotare, Uday ^{[1
]}

Yee, Karen W. L. ^{[1
]}

Le, Lisa W. ^{[2
]}

Porwit, Anna ^{[3
]}

Tierens, Anne ^{[3
]}

Musani, Rumina ^{[3
]}

Barth, David ^{[3
]}

Torlakovic, Emina ^{[3
]}

Schimmer, Aaron ^{[1
]}

Schuh, Andre C. ^{[1
]}

Seftel, Matthew ^{[1
,4
]}

Minden, Mark D. ^{[1
]}

Gupta, Vikas ^{[1
]}

Hyjek, Elizabeth ^{[3
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Leukemia Program, Div Med Oncol & Hematol, Toronto, ON, Canada

[2] Univ Hlth Network, Dept Biostat, Princess Margaret Canc Ctr, Toronto, ON, Canada

[3] Univ Hlth Network, Dept Pathobiol & Lab Med, Toronto, ON, Canada

[4] Canc Care Manitoba, Dept Med Oncol & Hematol, Winnipeg, MB, Canada

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2016年 / 91卷 / 03期

关键词：

TRANSPLANTATION; FEATURES; MUTATIONS; CRITERIA; OUTCOMES; MARROW;

D O I：

10.1002/ajh.24258

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Few studies describe the comprehensive immunophenotypic pattern of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in the bone marrow and its treatment. This retrospective analysis evaluates the diagnostic flow cytometry (FCM) pattern and outcome of nine patients diagnosed with BPDCN. A four-tube 10-color FCM panel used for diagnosis of acute leukemia (AL), showed cells in the blast gate (CD45dim/low SSC) and were positive for CD4(bright), CD33(dim), CD56(heterogenous), CD123(bright), CD36, CD38, HLA-DR, CD71. Seven patients received front-line induction therapy with HyperCVAD with an overall response rate of 86%. Five of six responders underwent planned allogeneic hematopoietic cell transplantation (allo-HCT). For a median follow up of 13.3 months, the 1-year disease free survival and overall survival were 56 and 67%, respectively. An accurate diagnosis of BPDCN can be made by 10-color FCM using a four-tube AL panel demonstrating a characteristic pattern of antigen expression. Front-line induction chemotherapy with HyperCVAD can yield high remission rates, but allo-HCT is required for long-term durable remissions. Am. J. Hematol. 91:283-286, 2016. (c) 2015 Wiley Periodicals, Inc.

引用

页码：283 / 286

页数：4

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