Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an Individual Participant Data Meta-Analysis of Congenital Zika Syndrome after Maternal Exposure during Pregnancy

被引：10

作者：

Costa Alecrim, Maria das Gracas ^{[1
]}

Ramos de Amorim, Melania Maria ^{[2
,3
]}

Barreto de Araujo, Thalia Velho ^{[4
]}

Brasil, Patricia ^{[5
]}

Brickley, Elizabeth B. ^{[6
]}

Castilho, Marcia da Costa ^{[1
]}

Coelho, Bernadete Perez ^{[7
]}

Ledo Alves da Cunha, Antonio Jose ^{[8
]}

Duarte, Geraldo ^{[9
]}

Estofolete, Cassia Fernanda ^{[10
]}

Gurgel, Ricardo Queiroz ^{[11
]}

Herrero-Silva, Juliana ^{[12
]}

Hofer, Cristina Barroso ^{[8
]}

Alves Lopes, Aline Siqueira ^{[11
]}

Turchi Martelli, Celina Maria ^{[13
]}

de Oliveira Melo, Adriana Suely ^{[2
,14
]}

Miranda-Filho, Democrito de Barros ^{[15
]}

Montarroyos, Ulisses Ramos ^{[16
]}

Moreira, Maria Elisabeth ^{[17
]}

Mussi-Pinhata, Marisa Marcia ^{[9
]}

de Oliveira, Consuelo Silva ^{[18
]}

Passos, Saulo Duarte ^{[19
]}

Prata-Barbosa, Arnaldo ^{[20
]}

dos Santos, Darci Neves ^{[21
]}

Schuler-Faccini, Lavinia ^{[22
]}

Moura da Silva, Antonio Augusto ^{[23
]}

de Siqueira, Isadora Cristina ^{[24
]}

Sousa, Patricia da Silva ^{[25
]}

Turchi, Marilia Dalva ^{[26
]}

de Alencar Ximenes, Ricardo Arraes ^{[15
,27
]}

de Sene Amancio Zara, Ana Laura ^{[26
]}

机构：

[1] Fundacao Med Trop Doutor Heitor Vieira Dourado, BR-69040000 Manaus, Amazonas, Brazil

[2] Univ Fed Campina Grande, BR-58428830 Campina Grande, Paraiba, Brazil

[3] Inst Med Integral Prof Fernando Figueira IMIP, BR-50070902 Recife, PE, Brazil

[4] Univ Fed Pernambuco, Dept Med Social, BR-50670901 Recife, PE, Brazil

[5] Fundacao Oswaldo Cruz, Inst Nacl Infectol Evandro Chagas, BR-21040360 Rio De Janeiro, Brazil

[6] London Sch Hyg & Trop Med, London WC1E 7HT, England

[7] Univ Fed Pernambuco, Ctr Ciencias Saude, BR-50670901 Recife, PE, Brazil

[8] Univ Fed Rio de Janeiro, Dept Pediat, BR-21941971 Rio De Janeiro, Brazil

[9] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, Brazil

[10] Fac Med Sao Jose do Rio Preto, BR-15090000 Sao Jose Do Rio Preto, Brazil

[11] Univ Fed Sergipe, BR-49060108 Aracaju, Brazil

[12] Secretaria Municipal Tangara da Serra, BR-78300000 Tangara Da Serra, Brazil

[13] Fundacao Oswaldo Cruz, Inst Aggeu Magalhaes, BR-50740465 Recife, PE, Brazil

[14] Inst Paraibano Diagnost EMBRION, BR-58400506 Campina Grande, Paraiba, Brazil

[15] Univ Pernambuco, Fac Ciencias Med, BR-50100130 Recife, PE, Brazil

[16] Univ Pernambuco, Inst Ciencias Biol, BR-50100130 Recife, PE, Brazil

[17] Fundacao Oswaldo Cruz, Inst Fernandes Figueira, BR-22250020 Rio De Janeiro, Brazil

[18] Inst Evandro Chagas, BR-67030000 Ananindeua, Brazil

[19] Fac Med Jundiai, BR-13211383 Jundiai, Brazil

[20] Inst DOr Pesquisa & Ensino, BR-22281100 Rio De Janeiro, Brazil

[21] Univ Fed Bahia, Inst Saude Colet, BR-40110040 Salvador, BA, Brazil

[22] Univ Fed Rio Grande do Sul, BR-91501970 Porto Alegre, RS, Brazil

[23] Univ Fed Maranhao, Dept Saude Publ, BR-65020070 Sao Luis, Maranhao, Brazil

[24] Ctr Pesquisas Goncalo Moniz, BR-40296710 Salvador, BA, Brazil

[25] Secretaria Saude Estado Maranhao, Ctr Referencia Neurodesenvolvimento, Assistencia & Reabilitacao Criancas, BR-65076820 Sao Luis, Maranhao, Brazil

[26] Univ Fed Goias, Dept Saude Colet, BR-74605050 Goiania, Go, Brazil

[27] Univ Fed Pernambuco, Dept Med Trop, BR-50670901 Recife, PE, Brazil

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 04期

基金：

英国惠康基金; 欧盟地平线“2020”; 巴西圣保罗研究基金会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

cohort; Zika; pregnant women; microcephaly; congenital Zika syndrome; IPD meta-analysis; VIRUS; INFANTS;

D O I：

10.3390/v13040687

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions.

引用

页数：13

共 24 条

[1] Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia [J].

Ades, A. E. ;

Brickley, Elizabeth B. ;

Alexander, Neal ;

Brown, David ;

Jaenisch, Thomas ;

Miranda-Filho, Democrito de Barros ;

Pohl, Moritz ;

Rosenberger, Kerstin D. ;

Soriano-Arandes, Antoni ;

Thorne, Claire ;

Ximenes, Ricardo Arraes de Alencar ;

de Araujo, Thalia Velho Barreto ;

Avelino-Silva, Vivian, I ;

Bethencourt Castillo, Sarah Esperanza ;

Borja Aburto, Victor Hugo ;

Brasil, Patricia ;

Christie, Celia D. C. ;

de Souza, Wayner Vieira ;

Gotuzzo, H. Jose Eduardo ;

Hoen, Bruno ;

Koopmans, Marion ;

Martelli, Celina Maria Turchi ;

Martins Teixeira, Mauro ;

Marques, Ernesto T. A. ;

Miranda, Maria Consuelo ;

Montarroyos, Ulisses Ramos ;

Moreira, Maria Elisabeth ;

Morris, J. Glenn ;

Rockx, Barry ;

Saba Villarroel, Paola Mariela ;

Soria Segarra, Carmen ;

Tami, Adriana ;

Turchi, Marilia Dalva ;

Giaquinto, Carlo ;

de Lamballerie, Xavier ;

Wilder-Smith, Annelies .

BMJ OPEN, 2020, 10 (12)

[2]

Albuquerque MDPM, 2016, EMERG INFECT DIS, V22, P1090, DOI [10.32032/eid2206.160062, 10.3201/eid2206.160062]

[3] Zika Virus Infection in Pregnant Women in Rio de Janeiro [J].

Brasil, P. ;

Pereira, J. P., Jr. ;

Moreira, M. E. ;

Ribeiro Nogueira, R. M. ;

Damasceno, L. ;

Wakimoto, M. ;

Rabello, R. S. ;

Valderramos, S. G. ;

Halai, U. -A. ;

Salles, T. S. ;

Zin, A. A. ;

Horovitz, D. ;

Daltro, P. ;

Boechat, M. ;

Gabaglia, C. Raja ;

Carvalho de Sequeira, P. ;

Pilotto, J. H. ;

Medialdea-Carrera, R. ;

Cotrim da Cunha, D. ;

Abreu de Carvalho, L. M. ;

Pone, M. ;

Machado Siqueira, A. ;

Calvet, G. A. ;

Rodrigues Baiao, A. E. ;

Neves, E. S. ;

Nassar de Carvalho, P. R. ;

Hasue, R. H. ;

Marschik, P. B. ;

Einspieler, C. ;

Janzen, C. ;

Cherry, J. D. ;

Bispo de Filippis, A. M. ;

Nielsen-Saines, K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (24) :2321-2334

[4] Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ [J].

Burke, Danielle L. ;

Ensor, Joie ;

Riley, Richard D. .

STATISTICS IN MEDICINE, 2017, 36 (05) :855-875

[5] Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil [J].

Cordeiro, Marli Tenorio ;

Pena, Lindomar J. ;

Brito, Carlos A. ;

Gil, Laura H. ;

Marques, Ernesto T. .

LANCET, 2016, 387 (10030) :1811-1812

[6] Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study [J].

de Araujo, Thalia Velho Barreto ;

Rodrigues, Laura Cunha ;

Ximenes, Ricardo Arraes de Alencar ;

Miranda-Filho, Democrito de Barros ;

Montarroyos, Ulisses Ramos ;

de Melo, Ana Paula Lopes ;

Valongueiro, Sandra ;

de Albuquerque, Maria de Fcitima Pessoa Militao ;

Souza, Wayner Vieira ;

Braga, Cynthia ;

Filho, Sinval Pinto Brandao ;

Cordeiro, Marli Tenorio ;

Vazquez, Enrique ;

Cruz, Danielle Di Cavalcanti Souza ;

Henriques, Clciudio Maierovitch Pessanha ;

Bezerra, Luciana Caroline Albuquerque ;

Castanha, Priscila Mayrelle da Silva ;

Dhalia, Rafael ;

Marques-Junior, Ernesto Torres Azevedo ;

Martelli, Celina Maria Turchi .

LANCET INFECTIOUS DISEASES, 2016, 16 (12) :1356-1363

[7] Individual Participant Data Meta-Analysis for a Binary Outcome: One-Stage or Two-Stage? [J].

Debray, Thomas P. A. ;

Moons, Karel G. M. ;

Abo-Zaid, Ghada Mohammed Abdallah ;

Koffijberg, Hendrik ;

Riley, Richard David .

PLOS ONE, 2013, 8 (04)

[8] Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation [J].

Franca, Giovanny V. A. ;

Schuler-Faccini, Lavinia ;

Oliveira, Wanderson K. ;

Henriques, Claudio M. P. ;

Carmo, Eduardo H. ;

Pedi, Vaneide D. ;

Nunes, Marilia L. ;

Castro, Marcia C. ;

Serruya, Suzanne ;

Silveira, Mariangela F. ;

Barros, Fernando C. ;

Victora, Cesar G. .

LANCET, 2016, 388 (10047) :891-897

[9] Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil [J].

Freitas, Bruno de Paula ;

de Oliveira Dias, Joao Rafael ;

Prazeres, Juliana ;

Sacramento, Gielson Almeida ;

Ko, Albert Icksang ;

Maia, Mauricio ;

Belfort, Rubens, Jr. .

JAMA OPHTHALMOLOGY, 2016, 134 (05) :529-535

[10] Computed Tomographic Findings in Microcephaly Associated with Zika Virus [J].

Hazin, Adriano N. ;

Poretti, Andrea ;

Turchi Martelli, Celina M. ;

Huisman, Thierry A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (22) :2193-2195

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