Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

被引：427

作者：

Cartier, Andreane ^{[1
,2
]}

Hla, Timothy ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Surg, Boston, MA 02115 USA

来源：

SCIENCE | 2019年 / 366卷 / 6463期

关键词：

SPHINGOSINE-1-PHOSPHATE RECEPTOR 2; BLOOD-BRAIN-BARRIER; TRANSPORTER SPNS2; CELL-MIGRATION; VASCULAR DEVELOPMENT; LYMPHOCYTE EGRESS; KIDNEY FIBROSIS; DOWN-REGULATION; MOUSE MODEL; FINGOLIMOD;

D O I：

10.1126/science.aar5551

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sphingosine 1-phosphate (S1P), a metabolic product of cell membrane sphingolipids, is bound to extracellular chaperones, is enriched in circulatory fluids, and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development, postnatal organ function, and disease. S1PRs regulate essential processes such as adaptive immune cell trafficking, vascular development, and homeostasis. Moreover, S1PR signaling is a driver of multiple diseases. The past decade has witnessed an exponential growth in this field, in part because of multidisciplinary research focused on this lipid mediator and the application of S1PR-targeted drugs in clinical medicine. This has revealed fundamental principles of lysophospholipid mediator signaling that not only clarify the complex and wide ranging actions of S1P but also guide the development of therapeutics and translational directions in immunological, cardiovascular, neurological, inflammatory, and fibrotic diseases.

引用

页码：323 / +

页数：13

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